acetic acid 3-acetoxy-2-(2-{[6-{2-[2-acetoxy-1-acetoxymethyl-2-(4-methylsulfanyl-phenyl)-ethylcarbamoyl]-phenylcarbamoyl}-4-(2-allyloxycarbonylamino-benzoylamino)-pyridine-2-carbonyl]-amino}-benzoylamino)-1-(4-methylsulfanyl-phenyl)-propyl ester

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Chemical Name:acetic acid 3-acetoxy-2-(2-{[6-{2-[2-acetoxy-1-acetoxymethyl-2-(4-methylsulfanyl-phenyl)-ethylcarbamoyl]-phenylcarbamoyl}-4-(2-allyloxycarbonylamino-benzoylamino)-pyridine-2-carbonyl]-amino}-benzoylamino)-1-(4-methylsulfanyl-phenyl)-propyl ester
CAS No.:638128-30-0
Molecular Formula:C₆₀H₅₉N₇O₁₅S₂
Molecular Weight:1182.3
Hs Code.:

acetic acid 3-acetoxy-2-(2-{[6-{2-[2-acetoxy-1-acetoxymethyl-2-(4-methylsulfanyl-phenyl)-ethylcarbamoyl]-phenylcarbamoyl}-4-(2-allyloxycarbonylamino-benzoylamino)-pyridine-2-carbonyl]-amino}-benzoylamino)-1-(4-methylsulfanyl-phenyl)-propyl ester

Synonyms:acetic acid 3-acetoxy-2-(2-{[6-{2-[2-acetoxy-1-acetoxymethyl-2-(4-methylsulfanyl-phenyl)-ethylcarbamoyl]-phenylcarbamoyl}-4-(2-allyloxycarbonylamino-benzoylamino)-pyridine-2-carbonyl]-amino}-benzoylamino)-1-(4-methylsulfanyl-phenyl)-propyl ester

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Chemical Property of acetic acid 3-acetoxy-2-(2-{[6-{2-[2-acetoxy-1-acetoxymethyl-2-(4-methylsulfanyl-phenyl)-ethylcarbamoyl]-phenylcarbamoyl}-4-(2-allyloxycarbonylamino-benzoylamino)-pyridine-2-carbonyl]-amino}-benzoylamino)-1-(4-methylsulfanyl-phenyl)-propyl ester

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Technology Process of acetic acid 3-acetoxy-2-(2-{[6-{2-[2-acetoxy-1-acetoxymethyl-2-(4-methylsulfanyl-phenyl)-ethylcarbamoyl]-phenylcarbamoyl}-4-(2-allyloxycarbonylamino-benzoylamino)-pyridine-2-carbonyl]-amino}-benzoylamino)-1-(4-methylsulfanyl-phenyl)-propyl ester

There total 9 articles about acetic acid 3-acetoxy-2-(2-{[6-{2-[2-acetoxy-1-acetoxymethyl-2-(4-methylsulfanyl-phenyl)-ethylcarbamoyl]-phenylcarbamoyl}-4-(2-allyloxycarbonylamino-benzoylamino)-pyridine-2-carbonyl]-amino}-benzoylamino)-1-(4-methylsulfanyl-phenyl)-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 308245-24-1
(1S,2S)-2-(2-aminobenzamido)-1-(4-methylthiophenyl)-1,3-propanediylbisacetate

: [2-(2,6-bis-chlorocarbonyl-pyridin-4-ylcarbamoyl)-phenyl]-carbamic acid allyl ester

: 638128-30-0
acetic acid 3-acetoxy-2-(2-{[6-{2-[2-acetoxy-1-acetoxymethyl-2-(4-methylsulfanyl-phenyl)-ethylcarbamoyl]-phenylcarbamoyl}-4-(2-allyloxycarbonylamino-benzoylamino)-pyridine-2-carbonyl]-amino}-benzoylamino)-1-(4-methylsulfanyl-phenyl)-propyl ester

Guidance literature:: With pyridine; dmap; In dichloromethane; at 20 ℃;
DOI:10.1021/ja037895a

Reference yield:

: 138-60-3
chelidamic acid

: 638128-30-0
acetic acid 3-acetoxy-2-(2-{[6-{2-[2-acetoxy-1-acetoxymethyl-2-(4-methylsulfanyl-phenyl)-ethylcarbamoyl]-phenylcarbamoyl}-4-(2-allyloxycarbonylamino-benzoylamino)-pyridine-2-carbonyl]-amino}-benzoylamino)-1-(4-methylsulfanyl-phenyl)-propyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: POCl₃ / 12 h / 128 °C

2: 1.79 g / 4-dimethylaminopyridine; pyridine / CH₂Cl₂ / 16 h / 20 °C

3: 97 percent / NaN₃ / dimethylformamide / 24 h / 50 °C

4: 98 percent / Pd/C; H₂ / ethyl acetate; methanol / 12 h / 20 °C / 2585.74 Torr

5: 93 percent / 4-dimethylaminopyridine; pyridine / CH₂Cl₂ / 3 h / 20 °C

6: 95 percent / Pd/C; H₂ / ethyl acetate; methanol / 12 h / 20 °C / 2585.74 Torr

7: 82 percent / 4-dimethylaminopyridine; pyridine / CH₂Cl₂ / 2.5 h / 20 °C

8: 92 percent / trifluoroacetic acid / CH₂Cl₂ / 2.5 h / 20 °C

9: DMF; oxalyl chloride / CH₂Cl₂ / 1.5 h / 20 °C

10: 360.6 mg / 4-dimethylaminopyridine; pyridine / CH₂Cl₂ / 20 °C

With pyridine; dmap; palladium on activated charcoal; sodium azide; oxalyl dichloride; hydrogen; N,N-dimethyl-formamide; trifluoroacetic acid; trichlorophosphate; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ja037895a

Reference yield:

: 638128-21-9
tert-butoxy 4-aminopyridine-2,6-dicarboxylate

: 638128-30-0
acetic acid 3-acetoxy-2-(2-{[6-{2-[2-acetoxy-1-acetoxymethyl-2-(4-methylsulfanyl-phenyl)-ethylcarbamoyl]-phenylcarbamoyl}-4-(2-allyloxycarbonylamino-benzoylamino)-pyridine-2-carbonyl]-amino}-benzoylamino)-1-(4-methylsulfanyl-phenyl)-propyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 93 percent / 4-dimethylaminopyridine; pyridine / CH₂Cl₂ / 3 h / 20 °C

2: 95 percent / Pd/C; H₂ / ethyl acetate; methanol / 12 h / 20 °C / 2585.74 Torr

3: 82 percent / 4-dimethylaminopyridine; pyridine / CH₂Cl₂ / 2.5 h / 20 °C

4: 92 percent / trifluoroacetic acid / CH₂Cl₂ / 2.5 h / 20 °C

5: DMF; oxalyl chloride / CH₂Cl₂ / 1.5 h / 20 °C

6: 360.6 mg / 4-dimethylaminopyridine; pyridine / CH₂Cl₂ / 20 °C

With pyridine; dmap; palladium on activated charcoal; oxalyl dichloride; hydrogen; N,N-dimethyl-formamide; trifluoroacetic acid; In methanol; dichloromethane; ethyl acetate;
DOI:10.1021/ja037895a