(1S,2S)-2-(2-aminobenzamido)-1-(4-methylthiophenyl)-1,3-propanediylbisacetate

Base Information

• Chemical Name: (1S,2S)-2-(2-aminobenzamido)-1-(4-methylthiophenyl)-1,3-propanediylbisacetate
• CAS No.: 308245-24-1
• Molecular Formula: C₂₁H₂₄N₂O₅S
• Molecular Weight: 416.498

Synonyms:(1S,2S)-2-(2-aminobenzamido)-1-(4-methylthiophenyl)-1,3-propanediylbisacetate

Chemical Property of (1S,2S)-2-(2-aminobenzamido)-1-(4-methylthiophenyl)-1,3-propanediylbisacetate

Chemical Property:

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Technology Process of (1S,2S)-2-(2-aminobenzamido)-1-(4-methylthiophenyl)-1,3-propanediylbisacetate

There total 4 articles about (1S,2S)-2-(2-aminobenzamido)-1-(4-methylthiophenyl)-1,3-propanediylbisacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(1S,2S)-2-(2-nitrobenzamido)-1-(4-methylthiophenyl)-1,3-propanediylbisacetate (308245-23-0) → (1S,2S)-2-(2-aminobenzamido)-1-(4-methylthiophenyl)-1,3-propanediylbisacetate (308245-24-1)

Guidance literature:

With hydrogen; 10percent Pd/C; In methanol; ethyl acetate; at 20 ℃; for 48h; under 760.051 Torr;

DOI:10.1021/ja001225c

Reference yield:

(1S,2S)-(+)-thiomicamine (16854-32-3) → (1S,2S)-2-(2-aminobenzamido)-1-(4-methylthiophenyl)-1,3-propanediylbisacetate (308245-24-1)

Guidance literature:

Multi-step reaction with 3 steps

1: DMAP; pyridine / 0 °C

2: pyridine; DMAP / 3 h / 60 °C

3: 97 percent / H₂ / 10percent Pd/C / ethyl acetate; methanol / 48 h / 20 °C / 760.05 Torr

With pyridine; dmap; hydrogen; 10percent Pd/C; In methanol; ethyl acetate;

DOI:10.1021/ja001225c

Reference yield:

2-nitrobenzyl chloride (610-14-0) → (1S,2S)-2-(2-aminobenzamido)-1-(4-methylthiophenyl)-1,3-propanediylbisacetate (308245-24-1)

Guidance literature:

Multi-step reaction with 3 steps

1: DMAP; pyridine / 0 °C

2: pyridine; DMAP / 3 h / 60 °C

3: 97 percent / H₂ / 10percent Pd/C / ethyl acetate; methanol / 48 h / 20 °C / 760.05 Torr

With pyridine; dmap; hydrogen; 10percent Pd/C; In methanol; ethyl acetate;

DOI:10.1021/ja001225c

upstream raw materials:

(1S,2S)-2-(2-nitrobenzamido)-1-(4-methylthiophenyl)-1,3-propanediylbisacetate

(1S,2S)-(+)-thiomicamine

2-nitrobenzyl chloride

Downstream raw materials:

4-chloro-2,6-bis[((2-(1S,2S)-1-(4-methylthiophenyl)-1,3-propanediylbisacetate)carbamoylphenyl)carbamoyl]pyridine

acetic acid 3-acetoxy-2-(2-{[6-{2-[2-acetoxy-1-acetoxymethyl-2-(4-methylsulfanyl-phenyl)-ethylcarbamoyl]-phenylcarbamoyl}-4-(2-allyloxycarbonylamino-benzoylamino)-pyridine-2-carbonyl]-amino}-benzoylamino)-1-(4-methylsulfanyl-phenyl)-propyl ester

4-amino-2,6-bis[((2-(1S,2S)-1-(4-methylthiophenyl)-1,3-propanediyl-bisacetate)carbamoylphenyl)carbamoyl]pyridine

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