Di-tert-butyl 4-aminopyridine-2,6-dicarboxylate

Base Information

Chemical Name:Di-tert-butyl 4-aminopyridine-2,6-dicarboxylate
CAS No.:638128-21-9
Molecular Formula:C15H22 N2 O4
Molecular Weight:294.351
Hs Code.:
DSSTox Substance ID:DTXSID90700885
Wikidata:Q82632377
Mol file:638128-21-9.mol

Synonyms:638128-21-9;Di-tert-butyl 4-aminopyridine-2,6-dicarboxylate;DTXSID90700885;Di-tert-butyl4-aminopyridine-2,6-dicarboxylate;Di-tert.-butyl 4-amino-2,6-pyridinedicarboxylate;J-400923

Suppliers and Price of Di-tert-butyl 4-aminopyridine-2,6-dicarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
2,6-DI-TERT-BUTYL 4-AMINOPYRIDINE-2,6-DICARBOXYLATE 95.00%
5MG
$ 502.30

Total 1 raw suppliers

Chemical Property of Di-tert-butyl 4-aminopyridine-2,6-dicarboxylate

Chemical Property:

Vapor Pressure:8.98E-08mmHg at 25°C
Refractive Index:1.526
Boiling Point:435.1°C at 760 mmHg
Flash Point:217°C
PSA：91.51000
Density:1.132g/cm³
LogP:3.15560
XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:294.15795719
Heavy Atom Count:21
Complexity:360

Purity/Quality:: 2,6-DI-TERT-BUTYL 4-AMINOPYRIDINE-2,6-DICARBOXYLATE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)C1=CC(=CC(=N1)C(=O)OC(C)(C)C)N

Technology Process of Di-tert-butyl 4-aminopyridine-2,6-dicarboxylate

There total 4 articles about Di-tert-butyl 4-aminopyridine-2,6-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 638128-20-8
tert-butoxy 4-azidopyridine-2,6-dicarboxylate

: 638128-21-9
tert-butoxy 4-aminopyridine-2,6-dicarboxylate

Guidance literature:: With palladium on activated charcoal; hydrogen; In methanol; ethyl acetate; at 20 ℃; for 12h; under 2585.74 Torr;
DOI:10.1021/ja037895a

Reference yield:

: 71022-75-8
4-chloropyridine-2,6-dicarbonyl dichloride

: 638128-21-9
tert-butoxy 4-aminopyridine-2,6-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.79 g / 4-dimethylaminopyridine; pyridine / CH₂Cl₂ / 16 h / 20 °C

2: 97 percent / NaN₃ / dimethylformamide / 24 h / 50 °C

3: 98 percent / Pd/C; H₂ / ethyl acetate; methanol / 12 h / 20 °C / 2585.74 Torr

With pyridine; dmap; palladium on activated charcoal; sodium azide; hydrogen; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ja037895a

Reference yield:

: 138-60-3
chelidamic acid

: 638128-21-9
tert-butoxy 4-aminopyridine-2,6-dicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: POCl₃ / 12 h / 128 °C

2: 1.79 g / 4-dimethylaminopyridine; pyridine / CH₂Cl₂ / 16 h / 20 °C

3: 97 percent / NaN₃ / dimethylformamide / 24 h / 50 °C

4: 98 percent / Pd/C; H₂ / ethyl acetate; methanol / 12 h / 20 °C / 2585.74 Torr

With pyridine; dmap; palladium on activated charcoal; sodium azide; hydrogen; trichlorophosphate; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ja037895a