tert-butyl (6R)-6-{[6-bromo-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]oxy}heptanoate

Base Information

Chemical Name:tert-butyl (6R)-6-{[6-bromo-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]oxy}heptanoate
CAS No.:1092938-86-7
Molecular Formula:C₂₄H₂₉BrN₂O₅
Molecular Weight:505.409
Hs Code.:

Synonyms:tert-butyl (6R)-6-{[6-bromo-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]oxy}heptanoate

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Chemical Property of tert-butyl (6R)-6-{[6-bromo-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]oxy}heptanoate

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Technology Process of tert-butyl (6R)-6-{[6-bromo-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]oxy}heptanoate

There total 9 articles about tert-butyl (6R)-6-{[6-bromo-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]oxy}heptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 1092938-85-6
tert-butyl (6R)-6-{[5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]oxy}heptanoate

: 1092938-86-7
tert-butyl (6R)-6-{[6-bromo-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]oxy}heptanoate

Guidance literature:: With N-Bromosuccinimide; In acetonitrile; at 20 ℃; for 2h; Inert atmosphere;

Reference yield:

: 62327-21-3
tert-butyl dimethylphosphonoacetate

: 1092938-86-7
tert-butyl (6R)-6-{[6-bromo-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]oxy}heptanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C / Cooling

1.2: -78 - 20 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 2 h / 20 °C / 760.05 Torr

3.1: phosphazene base-P₄-tert-butyl / hexane; tetrahydrofuran / 2.66 h / -10 - 20 °C / Inert atmosphere

4.1: N-Bromosuccinimide / acetonitrile / 2 h / 20 °C / Inert atmosphere

With N-Bromosuccinimide; hydrogen; sodium hydride; phosphazene base-P₄-tert-butyl; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; hexane; acetonitrile;

Reference yield:

: 1073630-51-9
(2E,6R)-6-hydroxyhept-2-enoic acid tert.-butyl ester

: 1092938-86-7
tert-butyl (6R)-6-{[6-bromo-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]oxy}heptanoate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / palladium 10% on activated carbon / ethanol / 2 h / 20 °C / 760.05 Torr

2: phosphazene base-P₄-tert-butyl / hexane; tetrahydrofuran / 2.66 h / -10 - 20 °C / Inert atmosphere

3: N-Bromosuccinimide / acetonitrile / 2 h / 20 °C / Inert atmosphere

With N-Bromosuccinimide; hydrogen; phosphazene base-P₄-tert-butyl; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; hexane; acetonitrile;