tert-butyl (6R)-6-[(5-cyclohex-1-en-1-yl-6-phenylfuro[2,3-d]pyrimidin-4-yl)oxy]heptanoate

Base Information

Chemical Name:tert-butyl (6R)-6-[(5-cyclohex-1-en-1-yl-6-phenylfuro[2,3-d]pyrimidin-4-yl)oxy]heptanoate
CAS No.:1092938-25-4
Molecular Formula:C₃₀H₃₈N₂O₅
Molecular Weight:506.642
Hs Code.:

Synonyms:tert-butyl (6R)-6-[(5-cyclohex-1-en-1-yl-6-phenylfuro[2,3-d]pyrimidin-4-yl)oxy]heptanoate

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Chemical Property of tert-butyl (6R)-6-[(5-cyclohex-1-en-1-yl-6-phenylfuro[2,3-d]pyrimidin-4-yl)oxy]heptanoate

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Technology Process of tert-butyl (6R)-6-[(5-cyclohex-1-en-1-yl-6-phenylfuro[2,3-d]pyrimidin-4-yl)oxy]heptanoate

There total 10 articles about tert-butyl (6R)-6-[(5-cyclohex-1-en-1-yl-6-phenylfuro[2,3-d]pyrimidin-4-yl)oxy]heptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1092938-86-7
tert-butyl (6R)-6-{[6-bromo-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]oxy}heptanoate

: 141091-37-4
2-(cyclohex-1-en-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1092938-25-4
tert-butyl (6R)-6-[(5-cyclohex-1-en-1-yl-6-phenylfuro[2,3-d]pyrimidin-4-yl)oxy]heptanoate

Guidance literature:: With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In water; dimethyl sulfoxide; at 80 ℃; for 3h; Inert atmosphere;

Reference yield:

: 62327-21-3
tert-butyl dimethylphosphonoacetate

: 1092938-25-4
tert-butyl (6R)-6-[(5-cyclohex-1-en-1-yl-6-phenylfuro[2,3-d]pyrimidin-4-yl)oxy]heptanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C / Cooling

1.2: -78 - 20 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 2 h / 20 °C / 760.05 Torr

3.1: phosphazene base-P₄-tert-butyl / hexane; tetrahydrofuran / 2.66 h / -10 - 20 °C / Inert atmosphere

4.1: N-Bromosuccinimide / acetonitrile / 2 h / 20 °C / Inert atmosphere

5.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / water; dimethyl sulfoxide / 3 h / 80 °C / Inert atmosphere

With N-Bromosuccinimide; hydrogen; sodium hydride; sodium carbonate; phosphazene base-P₄-tert-butyl; bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; hexane; water; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 123-11-5
4-methoxy-benzaldehyde

: 1092938-25-4
tert-butyl (6R)-6-[(5-cyclohex-1-en-1-yl-6-phenylfuro[2,3-d]pyrimidin-4-yl)oxy]heptanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: N,N-dimethylammonium chloride; potassium fluoride / dichloromethane; xylene / 15 h / 160 °C

2.1: ethanol / 0.17 h / 85 °C

2.2: 15 h / 85 °C

3.1: N,N-diethylaniline; trichlorophosphate / toluene / 37 h / 100 °C

4.1: phosphazene base-P₄-tert-butyl / hexane; tetrahydrofuran / 2.66 h / -10 - 20 °C / Inert atmosphere

5.1: N-Bromosuccinimide / acetonitrile / 2 h / 20 °C / Inert atmosphere

6.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / water; dimethyl sulfoxide / 3 h / 80 °C / Inert atmosphere

With potassium fluoride; N-Bromosuccinimide; N,N-dimethylammonium chloride; sodium carbonate; phosphazene base-P₄-tert-butyl; N,N-diethylaniline; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; ethanol; hexane; dichloromethane; water; dimethyl sulfoxide; toluene; acetonitrile; xylene;