1-[3-(benzyloxy)propyl]-5-(2-nitroprop-1-en-1-yl)indoline-7-carbonitrile

Base Information

Chemical Name:1-[3-(benzyloxy)propyl]-5-(2-nitroprop-1-en-1-yl)indoline-7-carbonitrile
CAS No.:1374461-77-4
Molecular Formula:C₂₂H₂₃N₃O₃
Molecular Weight:377.443
Hs Code.:

Synonyms:1-[3-(benzyloxy)propyl]-5-(2-nitroprop-1-en-1-yl)indoline-7-carbonitrile

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Chemical Property of 1-[3-(benzyloxy)propyl]-5-(2-nitroprop-1-en-1-yl)indoline-7-carbonitrile

Chemical Property:

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Technology Process of 1-[3-(benzyloxy)propyl]-5-(2-nitroprop-1-en-1-yl)indoline-7-carbonitrile

There total 6 articles about 1-[3-(benzyloxy)propyl]-5-(2-nitroprop-1-en-1-yl)indoline-7-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79-24-3
Nitroethane

: 1375180-30-5
1-[3-(benzyloxy)propyl]-5-formylindoline-7-carbonitrile

: 1374461-77-4
1-[3-(benzyloxy)propyl]-5-(2-nitroprop-1-en-1-yl)indoline-7-carbonitrile

Guidance literature:: Nitroethane; 1-[3-(benzyloxy)propyl]-5-formylindoline-7-carbonitrile; With ammonium acetate; at 125 ℃; for 4.5h;

With sodium sulfate; at 20 ℃; for 0.5h;

Reference yield:

: 100-39-0
benzyl bromide

: 1374461-77-4
1-[3-(benzyloxy)propyl]-5-(2-nitroprop-1-en-1-yl)indoline-7-carbonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide / tetra(n-butyl)ammonium hydrogensulfate / dichloromethane; water / 22 h / Reflux

2.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 25.5 h / 130 °C

3.1: trichlorophosphate / 1 h / 0 - 5 °C

3.2: 21.17 h / 20 °C / Cooling

3.3: 4 h / 35 °C

4.1: bromine; acetic acid / 0.67 h / 20 °C

5.1: N,N-dimethyl-formamide / 150 °C / Inert atmosphere

5.2: 0.25 h / 70 °C

6.1: ammonium acetate / 4.5 h / 125 °C

6.2: 0.5 h / 20 °C

With ammonium acetate; bromine; potassium carbonate; acetic acid; potassium iodide; sodium hydroxide; trichlorophosphate; tetra(n-butyl)ammonium hydrogensulfate; In dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 459868-64-5
1-[3-(benzyloxy)propyl]indoline

: 1374461-77-4
1-[3-(benzyloxy)propyl]-5-(2-nitroprop-1-en-1-yl)indoline-7-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: trichlorophosphate / 1 h / 0 - 5 °C

1.2: 21.17 h / 20 °C / Cooling

1.3: 4 h / 35 °C

2.1: bromine; acetic acid / 0.67 h / 20 °C

3.1: N,N-dimethyl-formamide / 150 °C / Inert atmosphere

3.2: 0.25 h / 70 °C

4.1: ammonium acetate / 4.5 h / 125 °C

4.2: 0.5 h / 20 °C

With ammonium acetate; bromine; acetic acid; trichlorophosphate; In N,N-dimethyl-formamide;