phenyl quinoline-6-carboxylate

Base Information

• Chemical Name: phenyl quinoline-6-carboxylate
• CAS No.: 53329-25-2
• Molecular Formula: C₁₆H₁₁NO₂
• Molecular Weight: 249.269
• Mol file: 53329-25-2.mol

Synonyms:phenyl quinoline-6-carboxylate

Chemical Property of phenyl quinoline-6-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of phenyl quinoline-6-carboxylate

There total 3 articles about phenyl quinoline-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

6-iodoquinoline (13327-31-6) + formic acid (64-18-6) + phenol (108-95-2,27073-41-2) → phenyl quinoline-6-carboxylate (53329-25-2)

Guidance literature:

With palladium diacetate; acetic anhydride; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In toluene; at 80 ℃; for 12h; Inert atmosphere;

DOI:10.1039/c5cy01957e

Reference yield: 40.0%

O-(6-quinolinyl) O-phenyl thiocarbonate (1271739-73-1) → quinolin-6-yl benzoate (81336-59-6) + phenyl quinoline-6-carboxylate (53329-25-2)

Guidance literature:

With triethylsilane; di-tert-butyl peroxide; In benzene; at 135 ℃; for 12h; regioselective reaction; Inert atmosphere; Sealed tube;

DOI:10.1021/jo102467j

Reference yield:

→ phenyl quinoline-6-carboxylate (53329-25-2)

Guidance literature:

Chinolin-6-carbonsaeure, SOCl2, Phenol;

DOI:10.1021/ja00824a033

upstream raw materials:

O-(6-quinolinyl) O-phenyl thiocarbonate

6-iodoquinoline

formic acid

phenol