1-benzyl-N-(4-{[(2-chloro-7-methylquinazolin-4-yl)amino]methyl}phenyl)piperidine-4-carboxamide

Base Information

• Chemical Name: 1-benzyl-N-(4-{[(2-chloro-7-methylquinazolin-4-yl)amino]methyl}phenyl)piperidine-4-carboxamide
• CAS No.: 1039736-11-2
• Molecular Formula: C₂₉H₃₀ClN₅O
• Molecular Weight: 500.043

Synonyms:1-benzyl-N-(4-{[(2-chloro-7-methylquinazolin-4-yl)amino]methyl}phenyl)piperidine-4-carboxamide

Chemical Property of 1-benzyl-N-(4-{[(2-chloro-7-methylquinazolin-4-yl)amino]methyl}phenyl)piperidine-4-carboxamide

Chemical Property:

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Technology Process of 1-benzyl-N-(4-{[(2-chloro-7-methylquinazolin-4-yl)amino]methyl}phenyl)piperidine-4-carboxamide

There total 1 articles about 1-benzyl-N-(4-{[(2-chloro-7-methylquinazolin-4-yl)amino]methyl}phenyl)piperidine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

7-methyl-2,4-dichloroquinazoline (25171-19-1) + N-[4-(aminomethyl)phenyl]-1-benzylpiperidine-4-carboxamide (1039736-72-5) → 1-benzyl-N-(4-{[(2-chloro-7-methylquinazolin-4-yl)amino]methyl}phenyl)piperidine-4-carboxamide (1039736-11-2)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1016/j.bmcl.2009.07.070

Reference yield: 90.0%

1-benzyl-N-(4-{[(2-chloro-7-methylquinazolin-4-yl)amino]methyl}phenyl)piperidine-4-carboxamide (1039736-11-2) + dimethyl amine (124-40-3) → 1-benzyl-N-[4-({[2-(dimethylamino)-7-methylquinazolin-4-yl]amino}methyl)phenyl]piperidine-4-carboxamide hydrochloride

Guidance literature:

With water; In tetrahydrofuran; at 100 ℃; for 26h;

Reference yield:

azetidine (503-29-7) + 1-benzyl-N-(4-{[(2-chloro-7-methylquinazolin-4-yl)amino]methyl}phenyl)piperidine-4-carboxamide (1039736-11-2) → N-(4-{[(2-azetidin-1-yl-7-methylquinazolin-4-yl)amino]methyl}phenyl)-1-benzylpiperidine-4-carboxamide (1039733-52-2)

Guidance literature:

In tetrahydrofuran; at 100 ℃; for 0.5h; Microwave irradiation;

DOI:10.1016/j.bmcl.2009.07.070

upstream raw materials:

7-methyl-2,4-dichloroquinazoline

N-[4-(aminomethyl)phenyl]-1-benzylpiperidine-4-carboxamide

Downstream raw materials:

N-(4-{[(2-azetidin-1-yl-7-methylquinazolin-4-yl)amino]methyl}phenyl)-1-benzylpiperidine-4-carboxamide

1-benzyl-N-(4-{[(7-methyl-2-pyrrolidin-1-ylquinazolin-4-yl)amino]methyl}phenyl)piperidine-4-carboxamide

1-benzyl-N-[4-({[7-methyl-2-(4-methylpiperazin-1-yl)quinazolin-4-yl]amino}methyl)phenyl]piperidine-4-carboxamide

C₃₅H₄₃N₇O

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