tert-butyl 4-(3-(5-chloro-6-(1-(phenylsulfonyl)-1H-indol-3-yl)pyridin-2-ylamino)phenylcarbamoyl)phenylcarbamate

Base Information

Chemical Name:tert-butyl 4-(3-(5-chloro-6-(1-(phenylsulfonyl)-1H-indol-3-yl)pyridin-2-ylamino)phenylcarbamoyl)phenylcarbamate
CAS No.:1604811-99-5
Molecular Formula:C₃₇H₃₂ClN₅O₅S
Molecular Weight:694.211
Hs Code.:

Synonyms:tert-butyl 4-(3-(5-chloro-6-(1-(phenylsulfonyl)-1H-indol-3-yl)pyridin-2-ylamino)phenylcarbamoyl)phenylcarbamate

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Chemical Property of tert-butyl 4-(3-(5-chloro-6-(1-(phenylsulfonyl)-1H-indol-3-yl)pyridin-2-ylamino)phenylcarbamoyl)phenylcarbamate

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Technology Process of tert-butyl 4-(3-(5-chloro-6-(1-(phenylsulfonyl)-1H-indol-3-yl)pyridin-2-ylamino)phenylcarbamoyl)phenylcarbamate

There total 5 articles about tert-butyl 4-(3-(5-chloro-6-(1-(phenylsulfonyl)-1H-indol-3-yl)pyridin-2-ylamino)phenylcarbamoyl)phenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1604811-98-4
5-chloro-6-(1-(phenylsulfonyl)-1H-indol-3-yl)pyridin-2-amine

: 1604811-97-3
tert-butyl 4-(3-bromophenylcarbamoyl)phenylcarbamate

: 1604811-99-5
tert-butyl 4-(3-(5-chloro-6-(1-(phenylsulfonyl)-1H-indol-3-yl)pyridin-2-ylamino)phenylcarbamoyl)phenylcarbamate

Guidance literature:: With potassium phosphate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In isopropyl alcohol; toluene; at 100 ℃; for 6h;

Reference yield:

: 66493-39-8
4-(N-tert-butoxycarbonyl)aminobenzoic acid

: 1604811-99-5
tert-butyl 4-(3-(5-chloro-6-(1-(phenylsulfonyl)-1H-indol-3-yl)pyridin-2-ylamino)phenylcarbamoyl)phenylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 2-(Dimethylamino)pyridine; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride / dichloromethane; N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 20 °C

2.1: palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; potassium phosphate / toluene; isopropyl alcohol / 6 h / 100 °C

With 2-(Dimethylamino)pyridine; potassium phosphate; palladium diacetate; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; toluene;

Reference yield:

: 19798-81-3,1184170-10-2
2-Amino-6-bromopyridine

: 1604811-99-5
tert-butyl 4-(3-(5-chloro-6-(1-(phenylsulfonyl)-1H-indol-3-yl)pyridin-2-ylamino)phenylcarbamoyl)phenylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: N-chloro-succinimide / acetonitrile / 18 h / 80 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / 1,4-dioxane; water / 3 h / 100 °C

3: palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; potassium phosphate / toluene; isopropyl alcohol / 6 h / 100 °C

With potassium phosphate; N-chloro-succinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; water; isopropyl alcohol; toluene; acetonitrile;