(E)-N-(3-(5-chloro-6-(1H-indol-3-yl)pyridin-2-ylamino)phenyl)-4-(4-(dimethylamino)but-2-enamido)benzamide

Base Information

Chemical Name:(E)-N-(3-(5-chloro-6-(1H-indol-3-yl)pyridin-2-ylamino)phenyl)-4-(4-(dimethylamino)but-2-enamido)benzamide
CAS No.:1604811-23-5
Molecular Formula:C₃₂H₂₉ClN₆O₂
Molecular Weight:565.074
Hs Code.:

Synonyms:(E)-N-(3-(5-chloro-6-(1H-indol-3-yl)pyridin-2-ylamino)phenyl)-4-(4-(dimethylamino)but-2-enamido)benzamide

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Chemical Property of (E)-N-(3-(5-chloro-6-(1H-indol-3-yl)pyridin-2-ylamino)phenyl)-4-(4-(dimethylamino)but-2-enamido)benzamide

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Technology Process of (E)-N-(3-(5-chloro-6-(1H-indol-3-yl)pyridin-2-ylamino)phenyl)-4-(4-(dimethylamino)but-2-enamido)benzamide

There total 9 articles about (E)-N-(3-(5-chloro-6-(1H-indol-3-yl)pyridin-2-ylamino)phenyl)-4-(4-(dimethylamino)but-2-enamido)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 99083-25-7
4-bromocrotonyl chloride

: 1604812-01-2
4-amino-N-(3-(5-chloro-6-(1H-indol-3-yl)pyridin-2-ylamino)phenyl)benzamide

: 124-40-3
dimethyl amine

: 1604811-23-5
(E)-N-(3-(5-chloro-6-(1H-indol-3-yl)pyridin-2-ylamino)phenyl)-4-(4-(dimethylamino)but-2-enamido)benzamide

Guidance literature:: 4-bromocrotonyl chloride; 4-amino-N-(3-(5-chloro-6-(1H-indol-3-yl)pyridin-2-ylamino)phenyl)benzamide; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at -60 ℃; for 4.5h;

dimethyl amine; In tetrahydrofuran; at 20 ℃; for 14h;

Reference yield:

: 66493-39-8
4-(N-tert-butoxycarbonyl)aminobenzoic acid

: 1604811-23-5
(E)-N-(3-(5-chloro-6-(1H-indol-3-yl)pyridin-2-ylamino)phenyl)-4-(4-(dimethylamino)but-2-enamido)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 2-(Dimethylamino)pyridine; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride / dichloromethane; N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 20 °C

2.1: palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; potassium phosphate / toluene; isopropyl alcohol / 6 h / 100 °C

3.1: trifluoroacetic acid / dichloromethane / 20 °C

4.1: sodium hydroxide / 1,4-dioxane / 24 h / 80 °C

5.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 4.5 h / -60 °C

5.2: 14 h / 20 °C

With 2-(Dimethylamino)pyridine; potassium phosphate; palladium diacetate; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; toluene;

Reference yield:

: 591-19-5
m-Bromoaniline

: 1604811-23-5
(E)-N-(3-(5-chloro-6-(1H-indol-3-yl)pyridin-2-ylamino)phenyl)-4-(4-(dimethylamino)but-2-enamido)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 2-(Dimethylamino)pyridine; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride / dichloromethane; N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 20 °C

2.1: palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; potassium phosphate / toluene; isopropyl alcohol / 6 h / 100 °C

3.1: trifluoroacetic acid / dichloromethane / 20 °C

4.1: sodium hydroxide / 1,4-dioxane / 24 h / 80 °C

5.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 4.5 h / -60 °C

5.2: 14 h / 20 °C

With 2-(Dimethylamino)pyridine; potassium phosphate; palladium diacetate; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; toluene;