3-biphenyl-4-yl-2-{[2-(N,N-dimethylamino)ethyl]-1-piperazino}-4-methoxylcarbonylmethyl-3,4-dihydroquinazoline

Base Information

Chemical Name:3-biphenyl-4-yl-2-{[2-(N,N-dimethylamino)ethyl]-1-piperazino}-4-methoxylcarbonylmethyl-3,4-dihydroquinazoline
CAS No.:1436857-65-6
Molecular Formula:C₃₁H₃₇N₅O₂
Molecular Weight:511.667
Hs Code.:

Synonyms:3-biphenyl-4-yl-2-{[2-(N,N-dimethylamino)ethyl]-1-piperazino}-4-methoxylcarbonylmethyl-3,4-dihydroquinazoline

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Chemical Property of 3-biphenyl-4-yl-2-{[2-(N,N-dimethylamino)ethyl]-1-piperazino}-4-methoxylcarbonylmethyl-3,4-dihydroquinazoline

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Technology Process of 3-biphenyl-4-yl-2-{[2-(N,N-dimethylamino)ethyl]-1-piperazino}-4-methoxylcarbonylmethyl-3,4-dihydroquinazoline

There total 4 articles about 3-biphenyl-4-yl-2-{[2-(N,N-dimethylamino)ethyl]-1-piperazino}-4-methoxylcarbonylmethyl-3,4-dihydroquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 3644-18-6
N-(2-(dimethylamino)ethyl)piperazine

: methyl trans-2-(3-biphenylcarbodiimido)cinnamate

: 1436857-65-6
3-biphenyl-4-yl-2-{[2-(N,N-dimethylamino)ethyl]-1-piperazino}-4-methoxylcarbonylmethyl-3,4-dihydroquinazoline

Guidance literature:: In toluene; at 20 ℃; for 2h;
DOI:10.5012/bkcs.2013.34.2.482

Reference yield:

: 1400645-09-1
methyl trans-2-(3-biphenylureido)cinnamate

: 1436857-65-6
3-biphenyl-4-yl-2-{[2-(N,N-dimethylamino)ethyl]-1-piperazino}-4-methoxylcarbonylmethyl-3,4-dihydroquinazoline

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; dibromotriphenylphosphorane / dichloromethane / 3 h / 0 °C / Inert atmosphere

2: toluene / 2 h / 20 °C

With triethylamine; dibromotriphenylphosphorane; In dichloromethane; toluene;
DOI:10.5012/bkcs.2013.34.2.482

Reference yield:

: 39228-29-0
(E)-methyl 2-nitrocinnamate

: 1436857-65-6
3-biphenyl-4-yl-2-{[2-(N,N-dimethylamino)ethyl]-1-piperazino}-4-methoxylcarbonylmethyl-3,4-dihydroquinazoline

Guidance literature:: Multi-step reaction with 4 steps

1.1: zinc; ammonium chloride / methanol / 12 h / 0 - 20 °C

2.1: diphenyl phosphoryl azide; triethylamine / toluene / 6 h / 20 - 100 °C

2.2: 12 h / 20 °C

3.1: triethylamine; dibromotriphenylphosphorane / dichloromethane / 3 h / 0 °C / Inert atmosphere

4.1: toluene / 2 h / 20 °C

With diphenyl phosphoryl azide; ammonium chloride; triethylamine; zinc; dibromotriphenylphosphorane; In methanol; dichloromethane; toluene; 2.1: |Curtius Rearrangement;
DOI:10.5012/bkcs.2013.34.2.482