N-(4-methoxybenzyl)-3-biphenyl-4-yl-2-{[2-(N,N-dimethylamino)ethyl]-1-piperazino}-4-methoxylcarbonylmethyl-3,4-dihydroquinazolin-4-ylacetamide

Base Information

Chemical Name:N-(4-methoxybenzyl)-3-biphenyl-4-yl-2-{[2-(N,N-dimethylamino)ethyl]-1-piperazino}-4-methoxylcarbonylmethyl-3,4-dihydroquinazolin-4-ylacetamide
CAS No.:1436857-67-8
Molecular Formula:C₃₈H₄₄N₆O₂
Molecular Weight:616.806
Hs Code.:

N-(4-methoxybenzyl)-3-biphenyl-4-yl-2-{[2-(N,N-dimethylamino)ethyl]-1-piperazino}-4-methoxylcarbonylmethyl-3,4-dihydroquinazolin-4-ylacetamide

Synonyms:N-(4-methoxybenzyl)-3-biphenyl-4-yl-2-{[2-(N,N-dimethylamino)ethyl]-1-piperazino}-4-methoxylcarbonylmethyl-3,4-dihydroquinazolin-4-ylacetamide

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Chemical Property of N-(4-methoxybenzyl)-3-biphenyl-4-yl-2-{[2-(N,N-dimethylamino)ethyl]-1-piperazino}-4-methoxylcarbonylmethyl-3,4-dihydroquinazolin-4-ylacetamide

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Technology Process of N-(4-methoxybenzyl)-3-biphenyl-4-yl-2-{[2-(N,N-dimethylamino)ethyl]-1-piperazino}-4-methoxylcarbonylmethyl-3,4-dihydroquinazolin-4-ylacetamide

There total 6 articles about N-(4-methoxybenzyl)-3-biphenyl-4-yl-2-{[2-(N,N-dimethylamino)ethyl]-1-piperazino}-4-methoxylcarbonylmethyl-3,4-dihydroquinazolin-4-ylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1436857-65-6
3-biphenyl-4-yl-2-{[2-(N,N-dimethylamino)ethyl]-1-piperazino}-4-methoxylcarbonylmethyl-3,4-dihydroquinazoline

: 2393-23-9
4-methoxy-benzylamine

: 1436857-67-8
N-(4-methoxybenzyl)-3-biphenyl-4-yl-2-{[2-(N,N-dimethylamino)ethyl]-1-piperazino}-4-methoxylcarbonylmethyl-3,4-dihydroquinazolin-4-ylacetamide

Guidance literature:: With 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; In neat (no solvent); for 12h;
DOI:10.5012/bkcs.2013.34.2.482

Reference yield:

: 88939-75-7
methyl (2E)-3-(2-aminophenyl)propenoate

: 1436857-67-8
N-(4-methoxybenzyl)-3-biphenyl-4-yl-2-{[2-(N,N-dimethylamino)ethyl]-1-piperazino}-4-methoxylcarbonylmethyl-3,4-dihydroquinazolin-4-ylacetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: diphenyl phosphoryl azide; triethylamine / toluene / 6 h / 20 - 100 °C

1.2: 12 h / 20 °C

2.1: triethylamine; dibromotriphenylphosphorane / dichloromethane / 3 h / 0 °C / Inert atmosphere

3.1: toluene / 2 h / 20 °C

4.1: 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine / neat (no solvent) / 12 h

With diphenyl phosphoryl azide; 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; triethylamine; dibromotriphenylphosphorane; In dichloromethane; toluene; 1.1: |Curtius Rearrangement;
DOI:10.5012/bkcs.2013.34.2.482

Reference yield:

: 1400645-09-1
methyl trans-2-(3-biphenylureido)cinnamate

: 1436857-67-8
N-(4-methoxybenzyl)-3-biphenyl-4-yl-2-{[2-(N,N-dimethylamino)ethyl]-1-piperazino}-4-methoxylcarbonylmethyl-3,4-dihydroquinazolin-4-ylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; dibromotriphenylphosphorane / dichloromethane / 3 h / 0 °C / Inert atmosphere

2: toluene / 2 h / 20 °C

3: 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine / neat (no solvent) / 12 h

With 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; triethylamine; dibromotriphenylphosphorane; In dichloromethane; toluene;
DOI:10.5012/bkcs.2013.34.2.482