N-(4-fluorobenzyl)-3-biphenyl-4-yl-2-{[2-(N,N-dimethylamino)ethyl]-1-piperazino}-4-methoxylcarbonylmethyl-3,4-dihydroquinazolin-4-ylacetamide

Base Information

Chemical Name:N-(4-fluorobenzyl)-3-biphenyl-4-yl-2-{[2-(N,N-dimethylamino)ethyl]-1-piperazino}-4-methoxylcarbonylmethyl-3,4-dihydroquinazolin-4-ylacetamide
CAS No.:1436857-66-7
Molecular Formula:C₃₇H₄₁FN₆O
Molecular Weight:604.771
Hs Code.:

N-(4-fluorobenzyl)-3-biphenyl-4-yl-2-{[2-(N,N-dimethylamino)ethyl]-1-piperazino}-4-methoxylcarbonylmethyl-3,4-dihydroquinazolin-4-ylacetamide

Synonyms:N-(4-fluorobenzyl)-3-biphenyl-4-yl-2-{[2-(N,N-dimethylamino)ethyl]-1-piperazino}-4-methoxylcarbonylmethyl-3,4-dihydroquinazolin-4-ylacetamide

Suppliers and Price of N-(4-fluorobenzyl)-3-biphenyl-4-yl-2-{[2-(N,N-dimethylamino)ethyl]-1-piperazino}-4-methoxylcarbonylmethyl-3,4-dihydroquinazolin-4-ylacetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(4-fluorobenzyl)-3-biphenyl-4-yl-2-{[2-(N,N-dimethylamino)ethyl]-1-piperazino}-4-methoxylcarbonylmethyl-3,4-dihydroquinazolin-4-ylacetamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(4-fluorobenzyl)-3-biphenyl-4-yl-2-{[2-(N,N-dimethylamino)ethyl]-1-piperazino}-4-methoxylcarbonylmethyl-3,4-dihydroquinazolin-4-ylacetamide

There total 6 articles about N-(4-fluorobenzyl)-3-biphenyl-4-yl-2-{[2-(N,N-dimethylamino)ethyl]-1-piperazino}-4-methoxylcarbonylmethyl-3,4-dihydroquinazolin-4-ylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1436857-65-6
3-biphenyl-4-yl-2-{[2-(N,N-dimethylamino)ethyl]-1-piperazino}-4-methoxylcarbonylmethyl-3,4-dihydroquinazoline

: 140-75-0
para-fluorobenzylamine

: 1436857-66-7
N-(4-fluorobenzyl)-3-biphenyl-4-yl-2-{[2-(N,N-dimethylamino)ethyl]-1-piperazino}-4-methoxylcarbonylmethyl-3,4-dihydroquinazolin-4-ylacetamide

Guidance literature:: With 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; In neat (no solvent); for 12h;
DOI:10.5012/bkcs.2013.34.2.482

Reference yield:

: 88939-75-7
methyl (2E)-3-(2-aminophenyl)propenoate

: 1436857-66-7
N-(4-fluorobenzyl)-3-biphenyl-4-yl-2-{[2-(N,N-dimethylamino)ethyl]-1-piperazino}-4-methoxylcarbonylmethyl-3,4-dihydroquinazolin-4-ylacetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: diphenyl phosphoryl azide; triethylamine / toluene / 6 h / 20 - 100 °C

1.2: 12 h / 20 °C

2.1: triethylamine; dibromotriphenylphosphorane / dichloromethane / 3 h / 0 °C / Inert atmosphere

3.1: toluene / 2 h / 20 °C

4.1: 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine / neat (no solvent) / 12 h

With diphenyl phosphoryl azide; 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; triethylamine; dibromotriphenylphosphorane; In dichloromethane; toluene; 1.1: |Curtius Rearrangement;
DOI:10.5012/bkcs.2013.34.2.482

Reference yield:

: 1400645-09-1
methyl trans-2-(3-biphenylureido)cinnamate

: 1436857-66-7
N-(4-fluorobenzyl)-3-biphenyl-4-yl-2-{[2-(N,N-dimethylamino)ethyl]-1-piperazino}-4-methoxylcarbonylmethyl-3,4-dihydroquinazolin-4-ylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; dibromotriphenylphosphorane / dichloromethane / 3 h / 0 °C / Inert atmosphere

2: toluene / 2 h / 20 °C

3: 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine / neat (no solvent) / 12 h

With 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; triethylamine; dibromotriphenylphosphorane; In dichloromethane; toluene;
DOI:10.5012/bkcs.2013.34.2.482