4-((4R,5S)-5-(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4-(m-tolyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one

Base Information

Chemical Name:4-((4R,5S)-5-(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4-(m-tolyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one
CAS No.:1370512-00-7
Molecular Formula:C₃₁H₃₃ClN₄O₄
Molecular Weight:561.08
Hs Code.:

Synonyms:4-((4R,5S)-5-(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4-(m-tolyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one

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Chemical Property of 4-((4R,5S)-5-(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4-(m-tolyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one

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Technology Process of 4-((4R,5S)-5-(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4-(m-tolyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one

There total 7 articles about 4-((4R,5S)-5-(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4-(m-tolyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5625-67-2
2-Ketopiperazine

: 75-44-5
phosgene

: C₁₅H₁₇ClN₂

: 107811-48-3
2-isopropoxy-4-methoxybenzene-1-carboaldehyde

: 1370511-97-9
4-((4S,5R)-4-(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-5-(m-tolyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one

: 1370511-98-0
4-((4R,5S)-4-(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-5-(m-tolyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one

: 1370511-99-1
4-((4S,5R)-5-(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4-(m-tolyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one

: 1370512-00-7
4-((4R,5S)-5-(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4-(m-tolyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one

Guidance literature:: C₁₅H₁₇ClN₂; 2-isopropoxy-4-methoxybenzene-1-carboaldehyde; With N-Bromosuccinimide; In dichloromethane; at 20 ℃; for 2h;

phosgene; With triethylamine; In dichloromethane; at 0 - 20 ℃; for 1h; Inert atmosphere;

2-Ketopiperazine; With triethylamine; In dichloromethane; at 0 - 20 ℃; for 2h;

Reference yield:

: 1373390-51-2
1-(2-(4-chlorophenyl)ethynyl)-3-methylbenzene

: 1370511-97-9
4-((4S,5R)-4-(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-5-(m-tolyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one

: 1370511-98-0
4-((4R,5S)-4-(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-5-(m-tolyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one

: 1370511-99-1
4-((4S,5R)-5-(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4-(m-tolyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one

: 1370512-00-7
4-((4R,5S)-5-(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4-(m-tolyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: palladium(II) iodide / dimethyl sulfoxide / 16 h / 135 °C

2.1: magnesium sulfate; hydroxylamine hydrochloride / pyridine; dimethyl sulfoxide / 32 h / 90 °C / Molecular sieve

3.1: sodium tetrahydroborate / 1,2-dimethoxyethane / 0.17 h / Cooling with ice

3.2: 18 h / 20 - 90 °C

3.3: 20 °C / pH 8

4.1: N-Bromosuccinimide / dichloromethane / 2 h / 20 °C

4.2: 1 h / 0 - 20 °C / Inert atmosphere

4.3: 2 h / 0 - 20 °C

With sodium tetrahydroborate; N-Bromosuccinimide; hydroxylamine hydrochloride; magnesium sulfate; palladium(II) iodide; In pyridine; 1,2-dimethoxyethane; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 591-17-3
meta-bromotoluene

: 1370511-97-9
4-((4S,5R)-4-(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-5-(m-tolyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one

: 1370511-98-0
4-((4R,5S)-4-(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-5-(m-tolyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one

: 1370511-99-1
4-((4S,5R)-5-(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4-(m-tolyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one

: 1370512-00-7
4-((4R,5S)-5-(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4-(m-tolyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / acetonitrile / 16 h / 60 °C / Inert atmosphere

1.2: 2 h / 20 °C

2.1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / acetonitrile / 16 h / 60 °C / Inert atmosphere

3.1: palladium(II) iodide / dimethyl sulfoxide / 16 h / 135 °C

4.1: magnesium sulfate; hydroxylamine hydrochloride / pyridine; dimethyl sulfoxide / 32 h / 90 °C / Molecular sieve

5.1: sodium tetrahydroborate / 1,2-dimethoxyethane / 0.17 h / Cooling with ice

5.2: 18 h / 20 - 90 °C

5.3: 20 °C / pH 8

6.1: N-Bromosuccinimide / dichloromethane / 2 h / 20 °C

6.2: 1 h / 0 - 20 °C / Inert atmosphere

6.3: 2 h / 0 - 20 °C

With sodium tetrahydroborate; N-Bromosuccinimide; hydroxylamine hydrochloride; magnesium sulfate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium(II) iodide; In pyridine; 1,2-dimethoxyethane; dichloromethane; dimethyl sulfoxide; acetonitrile;