7-(3,4-dichlorophenyl)-5-phenyl-2-thioxo-2,3-dihydro-1H-pyrrolo[2,3-d]pyrimidin-4(7H)-one

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Chemical Name:7-(3,4-dichlorophenyl)-5-phenyl-2-thioxo-2,3-dihydro-1H-pyrrolo[2,3-d]pyrimidin-4(7H)-one
CAS No.:1354047-21-4
Molecular Formula:C₁₈H₁₁Cl₂N₃OS
Molecular Weight:388.277
Hs Code.:

Synonyms:7-(3,4-dichlorophenyl)-5-phenyl-2-thioxo-2,3-dihydro-1H-pyrrolo[2,3-d]pyrimidin-4(7H)-one

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Chemical Property of 7-(3,4-dichlorophenyl)-5-phenyl-2-thioxo-2,3-dihydro-1H-pyrrolo[2,3-d]pyrimidin-4(7H)-one

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Technology Process of 7-(3,4-dichlorophenyl)-5-phenyl-2-thioxo-2,3-dihydro-1H-pyrrolo[2,3-d]pyrimidin-4(7H)-one

There total 2 articles about 7-(3,4-dichlorophenyl)-5-phenyl-2-thioxo-2,3-dihydro-1H-pyrrolo[2,3-d]pyrimidin-4(7H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1354047-18-9
C₁₇H₁₃Cl₂N₃O

: 17356-08-0
thiourea

: 1354047-21-4
7-(3,4-dichlorophenyl)-5-phenyl-2-thioxo-2,3-dihydro-1H-pyrrolo[2,3-d]pyrimidin-4(7H)-one

Guidance literature:: In ethanol; for 10h; Reflux;
DOI:10.1002/ardp.201100056

Reference yield:

: 888941-69-3
C₁₇H₁₁Cl₂N₃

: 1354047-21-4
7-(3,4-dichlorophenyl)-5-phenyl-2-thioxo-2,3-dihydro-1H-pyrrolo[2,3-d]pyrimidin-4(7H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride; acetic acid; sodium nitrite / water / 8.5 h / 0 - 20 °C

2: ethanol / 10 h / Reflux

With hydrogenchloride; acetic acid; sodium nitrite; In ethanol; water;
DOI:10.1002/ardp.201100056

Reference yield: 76.0%

: 1354047-21-4
7-(3,4-dichlorophenyl)-5-phenyl-2-thioxo-2,3-dihydro-1H-pyrrolo[2,3-d]pyrimidin-4(7H)-one

: 75-03-6
ethyl iodide

: 1354047-24-7
7-(3,4-dichlorophenyl)-2-(ethylthio)-5-phenyl-3H-pyrrolo[2,3-d]pyrimidine-4(7H)-one

Guidance literature:: 7-(3,4-dichlorophenyl)-5-phenyl-2-thioxo-2,3-dihydro-1H-pyrrolo[2,3-d]pyrimidin-4(7H)-one; With sodium; In ethanol; at 20 ℃; for 0.333333h;

With sodium ethanolate; for 5.5h; Reflux;

ethyl iodide;
DOI:10.1111/j.1747-0285.2012.01440.x