4-({3-[(E)-3-chloro-1-methyl-1-propenyl]phenoxy}methyl)-5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazole

Base Information

Chemical Name:4-({3-[(E)-3-chloro-1-methyl-1-propenyl]phenoxy}methyl)-5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazole
CAS No.:180084-75-7
Molecular Formula:C₂₂H₁₉ClF₃NO₂
Molecular Weight:421.847
Hs Code.:

Synonyms:4-({3-[(E)-3-chloro-1-methyl-1-propenyl]phenoxy}methyl)-5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazole

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Chemical Property of 4-({3-[(E)-3-chloro-1-methyl-1-propenyl]phenoxy}methyl)-5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazole

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Technology Process of 4-({3-[(E)-3-chloro-1-methyl-1-propenyl]phenoxy}methyl)-5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazole

There total 6 articles about 4-({3-[(E)-3-chloro-1-methyl-1-propenyl]phenoxy}methyl)-5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 174258-52-7
(E)-3-[3-({5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl}methoxy)phenyl]-2-buten-1-ol

: 180084-75-7
4-({3-[(E)-3-chloro-1-methyl-1-propenyl]phenoxy}methyl)-5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazole

Guidance literature:: With phosphorus pentachloride; calcium carbonate; In diethyl ether; at 0 ℃; for 0.5h;
DOI:10.1021/jm990476x

Reference yield:

: 455-19-6
4-Trifluoromethylbenzaldehyde

: 180084-75-7
4-({3-[(E)-3-chloro-1-methyl-1-propenyl]phenoxy}methyl)-5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazole

Guidance literature:: Multi-step reaction with 6 steps

1.1: 65 percent / HCl gas / ethyl acetate / 3 h / 5 °C

2.1: 30 percent / POCl₃ / CHCl₃ / 2.5 h / Heating

3.1: 82 percent / K₂CO₃ / dimethylformamide / 10 h / 65 °C

4.1: NaH / toluene / 1 h

4.2: 81 percent / toluene; tetrahydrofuran / 48 h

5.1: 95 percent / DIBAL / diethyl ether / 0.5 h / -78 °C

6.1: 35 percent / PCl₅; CaCO₃ / diethyl ether / 0.5 h / 0 °C

With hydrogenchloride; phosphorus pentachloride; sodium hydride; diisobutylaluminium hydride; potassium carbonate; calcium carbonate; trichlorophosphate; In diethyl ether; chloroform; ethyl acetate; N,N-dimethyl-formamide; toluene; 1.1: Condensation / 2.1: Chlorination / 3.1: Alkylation / 4.1: Metallation / 4.2: Condensation / 5.1: Reduction / 6.1: Chlorination;
DOI:10.1021/jm990476x

Reference yield:

: 174258-39-0
4-(chloromethyl)-5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazole

: 180084-75-7
4-({3-[(E)-3-chloro-1-methyl-1-propenyl]phenoxy}methyl)-5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: 82 percent / K₂CO₃ / dimethylformamide / 10 h / 65 °C

2.1: NaH / toluene / 1 h

2.2: 81 percent / toluene; tetrahydrofuran / 48 h

3.1: 95 percent / DIBAL / diethyl ether / 0.5 h / -78 °C

4.1: 35 percent / PCl₅; CaCO₃ / diethyl ether / 0.5 h / 0 °C

With phosphorus pentachloride; sodium hydride; diisobutylaluminium hydride; potassium carbonate; calcium carbonate; In diethyl ether; N,N-dimethyl-formamide; toluene; 1.1: Alkylation / 2.1: Metallation / 2.2: Condensation / 3.1: Reduction / 4.1: Chlorination;
DOI:10.1021/jm990476x