p-Dioxane-2,5-dimethanol

Base Information

• Chemical Name: p-Dioxane-2,5-dimethanol
• CAS No.: 14236-12-5
• Molecular Formula: C6H12 O4
• Molecular Weight: 148.159
• Hs Code.: 2934999090
• Mol file: 14236-12-5.mol

Synonyms:p-Dioxane-2,5-dimethanol(7CI,8CI)

Chemical Property of p-Dioxane-2,5-dimethanol

Chemical Property:

• Vapor Pressure: 0.000173mmHg at 25°C
• Melting Point: 91-93°C
• Refractive Index: 1.455
• Boiling Point: 294.2°C at 760 mmHg
• PKA: 13.94±0.10(Predicted)
• Flash Point: 131.7°C
• PSA: 58.92000
• Density: 1.178g/cm³
• LogP: -1.24500
• Storage Temp.: Refrigerator, Under Inert Atmosphere
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

Bis(2,5-hydroxymethyl)dioxane(MixtureofDiastereomers) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A component in beef flavoring. A derivative of dioxane. A component in beef flavoring. A derivative of dioxane

Technology Process of p-Dioxane-2,5-dimethanol

There total 12 articles about p-Dioxane-2,5-dimethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-benzyloxymethyl-5-hydroxymethyl-1,4-dioxane (338459-02-2) → 2,5-Bis(hydroxymethyl)-1,4-dioxane (14236-12-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃;

DOI:10.1002/1099-0690(200103)2001:5<875::AID-EJOC875>3.0.CO;2-R

Reference yield: 62.0%

4-hydroxymethyl-1,3-dioxolan-2-one (931-40-8) → 2,5-Bis(hydroxymethyl)-1,4-dioxane (14236-12-5) + 2,6-bis(hydroxymethyl)-1,4-dioxane + 3-(oxrian-2-yloxy)propane-1,2-diol (1416557-67-9) + oxiranyl-methanol (556-52-5)

Guidance literature:

With sodium chloride; at 175 ℃; for 0.75h; under 20.027 Torr;

DOI:10.1016/j.jcat.2012.10.015

Reference yield: 56.0%

2-[(2,3-epoxypropoxy)methyl]furan (5380-87-0) → 2,5-Bis(hydroxymethyl)-1,4-dioxane (14236-12-5)

Guidance literature:

With PhI(OH)OTs; In 1,2-dichloro-ethane; at 55 ℃; for 2h;

upstream raw materials:

dimethyl cis-1,4-dioxane-2,5-dicarboxylate

(+/-)-cis-[1,4]dioxane-2,5-dicarboxylic acid

glycerol

epichlorohydrin

Downstream raw materials:

cis-2,6-Bis(iodomethyl)-1,4-dioxane

(+/-)-cis-2,5-bis-(toluene-4-sulfonyloximethyl)-[1,4]dioxane

Refernces

• 1、 Choi, Ji Sik,Simanjuntaka, Fidelis Stefanus Hubertson,Oh, Ji Young,Lee, Keun Im,Lee, Sang Deuk,Cheong, Minserk,Kim, Hoon Sik,Lee, Hyunjoo. "Ionic-liquid-catalyzed decarboxylation of glycerol carbonate to glycidol". . p. 248 - 255. Retrieved 2013/02/23.
• 2、 Cassel, Stephanie,Debaig, Catherine,Benvegnu, Thierry,Chaimbault, Patrick,Lafosse, Michel,Plusquellec, Daniel,Rollin, Patrick. "Original synthesis of linear, branched and cyclic oligoglycerol standards". . p. 875 - 896. Retrieved 2007/10/03.