1H-Pyrazole-5-carboxamide, 1-(3-cyano-4-fluorophenyl)-N-[4-[2-[[[(1,1-dimethylethyl)dimethylsilyl]oxy] methyl]-1H-imidazol-1-yl]-2-fluorophenyl]-3-(trifluoromethyl)-

Base Information

Chemical Name:1H-Pyrazole-5-carboxamide, 1-(3-cyano-4-fluorophenyl)-N-[4-[2-[[[(1,1-dimethylethyl)dimethylsilyl]oxy] methyl]-1H-imidazol-1-yl]-2-fluorophenyl]-3-(trifluoromethyl)-
CAS No.:540510-49-4
Molecular Formula:C28H27F5N6O2Si
Molecular Weight:602.639
Hs Code.:

1H-Pyrazole-5-carboxamide,
1-(3-cyano-4-fluorophenyl)-N-[4-[2-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]
methyl]-1H-imidazol-1-yl]-2-fluorophenyl]-3-(trifluoromethyl)-

Synonyms:

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Chemical Property of 1H-Pyrazole-5-carboxamide, 1-(3-cyano-4-fluorophenyl)-N-[4-[2-[[[(1,1-dimethylethyl)dimethylsilyl]oxy] methyl]-1H-imidazol-1-yl]-2-fluorophenyl]-3-(trifluoromethyl)-

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Technology Process of 1H-Pyrazole-5-carboxamide, 1-(3-cyano-4-fluorophenyl)-N-[4-[2-[[[(1,1-dimethylethyl)dimethylsilyl]oxy] methyl]-1H-imidazol-1-yl]-2-fluorophenyl]-3-(trifluoromethyl)-

There total 6 articles about 1H-Pyrazole-5-carboxamide, 1-(3-cyano-4-fluorophenyl)-N-[4-[2-[[[(1,1-dimethylethyl)dimethylsilyl]oxy] methyl]-1H-imidazol-1-yl]-2-fluorophenyl]-3-(trifluoromethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 540510-48-3
1-(4-amino-3-fluorophenyl)-2-(tert-butyldimethylsilyloxymethyl)imidazole

: 754193-45-8
2-(3-cyano-4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carbonyl chloride

: 540510-49-4
N-[4-[(2-tert-butyldimethylsilyloxymethyl)-1H-imidazol-1-yl]-2-fluorophenyl]-1-(3-cyano-4-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

Guidance literature:: With dmap; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1021/jm0497949

Reference yield:

: 540510-47-2
1-(4-amino-3-fluorophenyl)-2-hydroxymethylimidazole

: 540510-49-4
N-[4-[(2-tert-butyldimethylsilyloxymethyl)-1H-imidazol-1-yl]-2-fluorophenyl]-1-(3-cyano-4-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 67 percent / Et₃N / dimethylformamide / 12 h / 20 °C

2: 0.48 g / DMAP / CH₂Cl₂ / 12 h / 20 °C

With dmap; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm0497949

Reference yield:

: 209960-58-7
1-(3-cyano-4-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic Acid

: 540510-49-4
N-[4-[(2-tert-butyldimethylsilyloxymethyl)-1H-imidazol-1-yl]-2-fluorophenyl]-1-(3-cyano-4-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl chloride; DMF / CH₂Cl₂ / 1 h / Heating

2: 0.48 g / DMAP / CH₂Cl₂ / 12 h / 20 °C

With dmap; oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane;
DOI:10.1021/jm0497949