trans-4,5-Bis-(4-chloro-phenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-1H-imidazole

Base Information

Chemical Name:trans-4,5-Bis-(4-chloro-phenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-1H-imidazole
CAS No.:844692-35-9
Molecular Formula:C₂₅H₂₄Cl₂N₂O₂
Molecular Weight:455.384
Hs Code.:

Synonyms:trans-4,5-Bis-(4-chloro-phenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-1H-imidazole

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Chemical Property of trans-4,5-Bis-(4-chloro-phenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-1H-imidazole

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Technology Process of trans-4,5-Bis-(4-chloro-phenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-1H-imidazole

There total 2 articles about trans-4,5-Bis-(4-chloro-phenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 548472-48-6
2-isopropoxy-4-methoxybenzimidic acid ethyl ester hydrochloride

: 86212-34-2,98674-96-5
meso-1,2-bis(4-chlorophenyl)ethylenediamine

: 144-55-8
sodium hydrogencarbonate

: 844692-35-9
trans-4,5-Bis-(4-chloro-phenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-1H-imidazole

Guidance literature:: With triethylamine; In methanol; diethyl ether; ethanol; dichloromethane; pentane;

Reference yield:

: 548472-48-6
2-isopropoxy-4-methoxybenzimidic acid ethyl ester hydrochloride

: 86212-34-2,98674-96-5
meso-1,2-bis(4-chlorophenyl)ethylenediamine

: 844692-35-9
trans-4,5-Bis-(4-chloro-phenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-1H-imidazole

Guidance literature:: With sodium hydrogencarbonate; triethylamine; In ethanol; dichloromethane;

Reference yield: 98.0%

: 844692-35-9
trans-4,5-Bis-(4-chloro-phenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-1H-imidazole

: 32315-10-9
bis(trichloromethyl) carbonate

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: C₃₅H₄₀Cl₂N₄O₅

Guidance literature:: trans-4,5-Bis-(4-chloro-phenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-1H-imidazole; bis(trichloromethyl) carbonate; With triethylamine; In dichloromethane; at 0 ℃; for 0.5h;

1-t-Butoxycarbonylpiperazine; at 0 - 20 ℃; for 0.5h;
DOI:10.1021/jacs.1c00703