Ethyl N,N-diethylphosphoramidochloridoite

Base Information

• Chemical Name: Ethyl N,N-diethylphosphoramidochloridoite
• CAS No.: 14114-77-3
• Molecular Formula: C6H15 Cl N O P
• Molecular Weight: 183.618
• DSSTox Substance ID: DTXSID30500109
• Mol file: 14114-77-3.mol

Synonyms:14114-77-3;Ethyl N,N-diethylphosphoramidochloridoite;N-[chloro(ethoxy)phosphanyl]-N-ethylethanamine;ethyl diethylamidochlorophosphite;DTXSID30500109;AKOS006284411

Chemical Property of Ethyl N,N-diethylphosphoramidochloridoite

Chemical Property:

• PSA: 26.06000
• LogP: 2.83040
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 183.0579788
• Heavy Atom Count: 10
• Complexity: 80.1

Purity/Quality:

99% ^*data from raw suppliers

CHLORO(DIETHYLAMINO)ETHOXYPHOSPHINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCN(CC)P(OCC)Cl

Technology Process of Ethyl N,N-diethylphosphoramidochloridoite

There total 6 articles about Ethyl N,N-diethylphosphoramidochloridoite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

O-ethyl chlorocyanophosphite (89129-84-0) + diethylamine (109-89-7) → O-ethyl (diethylamido)chlorophosphite (14114-77-3)

Guidance literature:

In benzene; at 20 - 60 ℃;

DOI:10.1007/BF00956374

Reference yield: 82.5%

phosphorodichloridous acid ethyl ester (1498-42-6) + diethylamine (109-89-7) → O-ethyl (diethylamido)chlorophosphite (14114-77-3)

Guidance literature:

DOI:10.1007/BF00950666

Reference yield: 53.0%

2-chloro-3-phenyl-[1,3,2]oxazaphospholidine (31707-07-0) + ethyl N,N'-tetraethyldiamidophosphite (2632-88-4) → O-ethyl (diethylamido)chlorophosphite (14114-77-3) + N,N-diethyl-3-phenyl-1,3,2-oxazaphospholidin-2-amine (31707-09-2)

Guidance literature:

at 150 ℃; for 1h;

DOI:10.1007/BF00953486

upstream raw materials:

ethyl dichlorothiophosphite

diethylamine

phosphorodichloridous acid ethyl ester

ethyl N,N'-tetraethyldiamidophosphite

Downstream raw materials:

3-<(diethylaminoethoxyphosphino)thio>indole

C₁₄H₂₁N₂OPS

difluoro diethylamino phosphine

o-acetylphenyl ethyl diethylphosphoramidite