Ethyl dichlorophosphite

Base Information

• Chemical Name: Ethyl dichlorophosphite
• CAS No.: 1498-42-6
• Molecular Formula: C2H5 Cl2 O P
• Molecular Weight: 146.941
• Hs Code.: 2909199090
• European Community (EC) Number: 216-098-5
• DSSTox Substance ID: DTXSID50164383
• Nikkaji Number: J206.702A
• Wikidata: Q72471483
• Mol file: 1498-42-6.mol

Synonyms:Ethyl dichlorophosphite;Ethyl phosphorodichloridite;1498-42-6;dichloro(ethoxy)phosphane;ethyl dichlorophosphinite;ETHYLPHOSPHORODICHLORIDITE;EINECS 216-098-5;Dichloroethoxyphosphine;C2H5OPCl2;Ethyl dichloridophosphite #;SCHEMBL6160;Ethyl dichlorophosphite, 98%;DTXSID50164383;GEO-01338;MFCD00000525;phosphorodichloridous acid ethyl ester;AKOS005254496;AT25036;Phosphorodichloridous acid, ethyl ester;FT-0625790;EN300-304969;J-008633

Chemical Property of Ethyl dichlorophosphite

Chemical Property:

• Vapor Pressure: 21.7mmHg at 25°C
• Refractive Index: n20/D 1.464(lit.)
• Boiling Point: 117-118 °C(lit.)
• Flash Point: 40 °F
• PSA: 22.82000
• Density: 1.286 g/mL at 25 °C(lit.)
• LogP: 2.72740
• Storage Temp.: Refrigerator (+4°C) + Flammables area
• Sensitive.: Moisture Sensitive
• Water Solubility.: Reacts with water.
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 145.9455072
• Heavy Atom Count: 6
• Complexity: 32.7

Purity/Quality:

98%,99%, ^*data from raw suppliers

Ethyl dichlorophosphite ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F,C
• Hazard Codes: F,C
• Statements: 11-34
• Safety Statements: 16-26-27-36/37/39-45

MSDS Files:

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCOP(Cl)Cl
• Uses: Ethyl dichlorophosphite is used in the synthesis of peptide derivatives. It is used as an anhydride forming reagent. Ethyl dichlorophosphite was used in the synthesis of peptide derivatives.

Technology Process of Ethyl dichlorophosphite

There total 30 articles about Ethyl dichlorophosphite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

diethyl phosphorylchloridite (589-57-1) + methyl 2,2-dichloro-2-methoxyacetate (17640-25-4) → Dimethyl oxalate (553-90-2) + phosphorodichloridous acid ethyl ester (1498-42-6) + chloroethane (75-00-3) + phosphonic dichloride (66298-75-7) + ethyl phosphonochloridate (74813-30-2) + phosphonic dichloride

Guidance literature:

With iron(III) chloride; at 105 - 110 ℃; for 0.833333h; Product distribution;

Reference yield: 85.0%

ethyl trimethylsilyl ether (1825-62-3) → phosphorodichloridous acid ethyl ester (1498-42-6)

Guidance literature:

With pyridine; phosphorus trichloride; In dichloromethane; at -65 - 20 ℃; for 27h; Inert atmosphere; Sealed tube;

DOI:10.1080/10426500902719222

Reference yield: 65.0%

phosphorodicyanidous acid ethyl ester (33326-13-5) + acetyl chloride (75-36-5) → phosphorodichloridous acid ethyl ester (1498-42-6)

Guidance literature:

triethylamine; at 80 ℃; for 0.5h;

upstream raw materials:

ethanol

Triethyl orthopropionate

triethyl phosphite

diethyl phosphorylchloridite

Downstream raw materials:

Ethyl hydrogen hydroxyphenylmethylphosphonate

diethyl phosphorylchloridite

2-chloro-1,3-dibutyl-4,5-dimethyl-1,3,2-diazaphospholine

chloroethane

Refernces

• 1、 Ebetino, Frank H.,Berk, Jeffrey D.. "A stereoselective process for the preparation of novel phosphonoalkylphosphinates". . p. 135 - 142. Retrieved 1997.
• 2、 Arkhypchuk, Anna I.,Santoni, Marie-Pierre,Ott, Sascha. "Revisiting the phospha-Wittig-Horner reaction". experimental part. p. 1118 - 1126. Retrieved 2012/04/10.
• 3、 Gazizov,Khairullina,Ibragimov,Karimova,Bagautdinova,Sinyashin. "Reaction of acyl halides and P(III) chlorides with alkyl diphenyl(or triphenyl)methyl ethers [2]". . p. 309 - 311. Retrieved 2008/01/08.