2-(3-tert-Butoxycarbonylamino-2-hydroxy-3-phenyl-propionylamino)-3-methyl-butyric acid methyl ester

Base Information

• Chemical Name: 2-(3-tert-Butoxycarbonylamino-2-hydroxy-3-phenyl-propionylamino)-3-methyl-butyric acid methyl ester
• CAS No.: 161167-76-6
• Molecular Formula: C₂₀H₃₀N₂O₆
• Molecular Weight: 394.468

Synonyms:2-(3-tert-Butoxycarbonylamino-2-hydroxy-3-phenyl-propionylamino)-3-methyl-butyric acid methyl ester

Chemical Property of 2-(3-tert-Butoxycarbonylamino-2-hydroxy-3-phenyl-propionylamino)-3-methyl-butyric acid methyl ester

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Technology Process of 2-(3-tert-Butoxycarbonylamino-2-hydroxy-3-phenyl-propionylamino)-3-methyl-butyric acid methyl ester

There total 3 articles about 2-(3-tert-Butoxycarbonylamino-2-hydroxy-3-phenyl-propionylamino)-3-methyl-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,1-dimethyl (2-oxo-1-phenylethyl)carbamate (140196-38-9) → 2-(3-tert-Butoxycarbonylamino-2-hydroxy-3-phenyl-propionylamino)-3-methyl-butyric acid methyl ester (161167-76-6)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / Ambient temperature

2: Et₃N / 36 h / Ambient temperature

With triethylamine; In dichloromethane;

DOI:10.1016/0040-4020(96)00143-3

Reference yield:

4-(1-methylethyl)-2-oxazolin-5-one (4526-83-4) → 2-(3-tert-Butoxycarbonylamino-2-hydroxy-3-phenyl-propionylamino)-3-methyl-butyric acid methyl ester (161167-76-6)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / Ambient temperature

2: Et₃N / 36 h / Ambient temperature

With triethylamine; In dichloromethane;

DOI:10.1016/0040-4020(96)00143-3

Reference yield:

methanol (67-56-1) + [2-Hydroxy-2-(4-isopropyl-5-oxo-2,5-dihydro-oxazol-2-yl)-1-phenyl-ethyl]-carbamic acid tert-butyl ester (161060-38-4) → 2-(3-tert-Butoxycarbonylamino-2-hydroxy-3-phenyl-propionylamino)-3-methyl-butyric acid methyl ester (161167-76-6)

Guidance literature:

With triethylamine; for 36h; Ambient temperature;

DOI:10.1016/0040-4020(96)00143-3

upstream raw materials:

methanol

[2-Hydroxy-2-(4-isopropyl-5-oxo-2,5-dihydro-oxazol-2-yl)-1-phenyl-ethyl]-carbamic acid tert-butyl ester

1,1-dimethyl (2-oxo-1-phenylethyl)carbamate

4-(1-methylethyl)-2-oxazolin-5-one

Downstream raw materials:

3-Amino-2-hydroxy-3-phenyl-propionic acid methyl ester

syn-(+/-)-2-hydroxy-3-(benzoylamino)-3-phenylpropanoic acid methyl ester

methyl (2S,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoate

(2R,3R)-(-)-2-hydroxy-3-(benzoylamino)-3-phenylpropanoic acid methyl ester

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