3-Methoxy-4-hydroxyphenylacetylene

Base Information

Chemical Name:3-Methoxy-4-hydroxyphenylacetylene
CAS No.:14031-76-6
Molecular Formula:C9H8 O2
Molecular Weight:148.161
Hs Code.:2909500000
DSSTox Substance ID:DTXSID30486479
Nikkaji Number:J2.903.039A
Wikidata:Q82327479
Mol file:14031-76-6.mol

Synonyms:3-methoxy-4-hydroxyphenylacetylene;4-ethynyl-2-methoxyphenol;14031-76-6;4-ETHYNYL-2-METHOXY-PHENOL;SCHEMBL5974207;DTXSID30486479;WMNRKIVJDZUMOE-UHFFFAOYSA-N;AKOS006289769;EN300-1828042

Suppliers and Price of 3-Methoxy-4-hydroxyphenylacetylene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
4-ETHYNYL-2-METHOXY-PHENOL 95.00%
5MG
$ 500.13

Total 5 raw suppliers

Chemical Property of 3-Methoxy-4-hydroxyphenylacetylene

Chemical Property:

PSA：29.46000
LogP:1.38210
XLogP3:1.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:148.052429494
Heavy Atom Count:11
Complexity:168

Purity/Quality:

97% ^*data from raw suppliers

4-ETHYNYL-2-METHOXY-PHENOL 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=CC(=C1)C#C)O

Technology Process of 3-Methoxy-4-hydroxyphenylacetylene

There total 11 articles about 3-Methoxy-4-hydroxyphenylacetylene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 173531-47-0
tert-butyl-(4-ethynyl-2-methoxyphenoxy)dimethylsilane

: 14031-76-6
4-hydroxy-3-methoxyphenylacetylene

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃; for 2.5h;
DOI:10.1002/ejoc.201500931

Reference yield: 88.0%

: 218903-31-2
4-(2,2-dibromovinyl)-2-methoxyphenol

: 14031-76-6
4-hydroxy-3-methoxyphenylacetylene

Guidance literature:: With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 3h; Inert atmosphere;
DOI:10.1021/acs.joc.1c00598

Reference yield: 78.0%

: 558-13-4
carbon tetrabromide

: 121-33-5,8014-42-4
vanillin

: 14031-76-6
4-hydroxy-3-methoxyphenylacetylene

Guidance literature:: carbon tetrabromide; vanillin; With triisopropyl phosphite; In acetonitrile; at 0 ℃; for 0.166667h;

With 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium hydroxide; In acetonitrile; at 0 - 20 ℃; for 5h;
DOI:10.1002/adsc.201801334