7-Methoxy-8-methyl-chromen-2-one

Base Information

• Chemical Name: 7-Methoxy-8-methyl-chromen-2-one
• CAS No.: 14002-94-9
• Molecular Formula: C11H10 O3
• Molecular Weight: 190.199
• Hs Code.: 2932209090
• DSSTox Substance ID: DTXSID10459040
• Wikidata: Q82282642
• Mol file: 14002-94-9.mol

Synonyms:7-methoxy-8-methyl-chromen-2-one;14002-94-9;7-Methoxy-8-methyl-2H-chromen-2-one;7-METHOXY-8-METHYLCHROMEN-2-ONE;7-methoxy-8-methyl-coumarin;SCHEMBL4181037;DTXSID10459040;AKOS006291349;AC-20783

Chemical Property of 7-Methoxy-8-methyl-chromen-2-one

Chemical Property:

• Vapor Pressure: 0.000103mmHg at 25°C
• Refractive Index: 1.565
• Boiling Point: 337.8°C at 760 mmHg
• Flash Point: 139.7°C
• PSA: 39.44000
• Density: 1.208g/cm³
• LogP: 2.11000
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 190.062994177
• Heavy Atom Count: 14
• Complexity: 259

Purity/Quality:

99% ^*data from raw suppliers

7-METHOXY-8-METHYL-CHROMEN-2-ONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C=CC2=C1OC(=O)C=C2)OC

Technology Process of 7-Methoxy-8-methyl-chromen-2-one

There total 10 articles about 7-Methoxy-8-methyl-chromen-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

7-hydroxy-8-methyl-2H-chromen-2-one (2732-17-4) + methyl iodide (74-88-4) → 7-methoxy-8-methyl-2H-chromen-2-one (14002-94-9)

Guidance literature:

7-hydroxy-8-methyl-2H-chromen-2-one; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.333333h;

methyl iodide; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 5h;

DOI:10.1021/jm049535j

Reference yield: 31.0%

5-methoxymethylene-2,2-dimethyl-1,3-dioxane-4,6-dione (15568-85-1) + 3-methoxy-2-methylphenol (6971-52-4) → 7-methoxy-8-methyl-2H-chromen-2-one (14002-94-9)

Guidance literature:

With ytterbium(III) triflate; In nitromethane; at 100 ℃; for 1.5h;

DOI:10.1021/jo052000t

Reference yield:

trimethyl phosphite (512-56-1) + 7-hydroxy-2H-chromen-2-one (93-35-6) → 7-methoxycoumarin (531-59-9) + 7-methoxy-8-methyl-2H-chromen-2-one (14002-94-9)

Guidance literature:

With boron trifluoride; In diethyl ether; for 0.025h; microwave irradiation;

DOI:10.1080/714040947

upstream raw materials:

7-hydroxy-2H-chromen-2-one

methyl iodide

7-hydroxy-8-methyl-2H-chromen-2-one

trimethyl phosphite

Downstream raw materials:

2-hydroxy-4-methoxy-3-methylbenzoic acid