5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-2-oxo-4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrobromide

Base Information

Chemical Name:5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-2-oxo-4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrobromide
CAS No.:1190589-94-6
Molecular Formula:BrH*C₁₈H₁₈FNO₂S
Molecular Weight:412.323
Hs Code.:

Synonyms:5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-2-oxo-4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrobromide

Suppliers and Price of 5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-2-oxo-4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrobromide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-2-oxo-4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrobromide

Chemical Property:

Purity/Quality:: 98% HPLC ^*data from raw suppliers

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Technology Process of 5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-2-oxo-4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrobromide

There total 4 articles about 5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-2-oxo-4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 951380-42-0
5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-2-oxo-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

: 1190589-94-6
5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-2-oxo-4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrobromide

Guidance literature:: With hydrogen bromide; In acetic acid; acetone; at 0 - 5 ℃; for 1h;

Reference yield:

: 446-48-0
o-fluorobenzyl bromide

: 1190589-94-6
5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-2-oxo-4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrobromide

Guidance literature:: Multi-step reaction with 4 steps

1.1: magnesium / methyl iodide / diethyl ether / 20 °C

1.2: 20 °C

1.3: 0 °C

2.1: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; 2,2'-azobis(isobutyronitrile) / cyclohexane / 10 °C / Reflux

3.1: potassium hydrogencarbonate / acetonitrile / 10 - 15 °C

4.1: hydrogen bromide / acetic acid; acetone / 1 h / 0 - 5 °C

With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; 2,2'-azobis(isobutyronitrile); hydrogen bromide; potassium hydrogencarbonate; magnesium; methyl iodide; In diethyl ether; cyclohexane; acetic acid; acetone; acetonitrile;

Reference yield:

: 204205-33-4
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone

: 1190589-94-6
5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-2-oxo-4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrobromide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydrogencarbonate / acetonitrile / 10 - 15 °C

2: hydrogen bromide / acetic acid; acetone / 1 h / 0 - 5 °C

With hydrogen bromide; potassium hydrogencarbonate; In acetic acid; acetone; acetonitrile;