[2,6-bis(methoxymethoxy)-4-methylphenyl][3-chloro-6-hydroxymethyl-4-methoxy-2-(methoxymethoxy)phenyl]-methanone

Base Information

• Chemical Name: [2,6-bis(methoxymethoxy)-4-methylphenyl][3-chloro-6-hydroxymethyl-4-methoxy-2-(methoxymethoxy)phenyl]-methanone
• CAS No.: 1320259-70-8
• Molecular Formula: C₂₂H₂₇ClO₉
• Molecular Weight: 470.904
• Mol file: 1320259-70-8.mol

Synonyms:[2,6-bis(methoxymethoxy)-4-methylphenyl][3-chloro-6-hydroxymethyl-4-methoxy-2-(methoxymethoxy)phenyl]-methanone

Chemical Property of [2,6-bis(methoxymethoxy)-4-methylphenyl][3-chloro-6-hydroxymethyl-4-methoxy-2-(methoxymethoxy)phenyl]-methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [2,6-bis(methoxymethoxy)-4-methylphenyl][3-chloro-6-hydroxymethyl-4-methoxy-2-(methoxymethoxy)phenyl]-methanone

There total 13 articles about [2,6-bis(methoxymethoxy)-4-methylphenyl][3-chloro-6-hydroxymethyl-4-methoxy-2-(methoxymethoxy)phenyl]-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[2,6-bis(methoxymethoxy)-4-methylphenyl][3-chloro-4-methoxy-2-(methoxymethoxy)-6-[(phenylmethoxy)methyl]phenyl]-methanone (1320259-68-4) → [2,6-bis(methoxymethoxy)-4-methylphenyl][3-chloro-6-hydroxymethyl-4-methoxy-2-(methoxymethoxy)phenyl]-methanone (1320259-70-8)

Guidance literature:

With Pd-BaSO₄; hydrogen; In ethanol; at 20 ℃; for 0.833333h;

DOI:10.1021/ol201561w

Reference yield:

[2,6-bis(methoxymethoxy)-4-methylphenyl][3-chloro-4-methoxy-2-(methoxymethoxy)-6-[(phenylmethoxy)methyl]phenyl]-methanone (1320259-68-4) → C22H27ClO9 (1346458-46-5) + [2,6-bis(methoxymethoxy)-4-methylphenyl][3-chloro-6-hydroxymethyl-4-methoxy-2-(methoxymethoxy)phenyl]-methanone (1320259-70-8)

Guidance literature:

With 20 % Pd(OH)2/C; hydrogen; In methanol; at 20 ℃;

DOI:10.1021/ol201561w

Reference yield:

2,6-bis(methoxymethoxy)-α-[3-chloro-4-methoxy-2-methoxymethoxy-6-[(phenylmethoxy)-methyl]]-4-methyl-benzenemethanol (1320259-67-3) → [2,6-bis(methoxymethoxy)-4-methylphenyl][3-chloro-6-hydroxymethyl-4-methoxy-2-(methoxymethoxy)phenyl]-methanone (1320259-70-8)

Guidance literature:

Multi-step reaction with 2 steps

1: Dess-Martin periodane / dichloromethane / 3.5 h / 25 °C / Inert atmosphere

2: Pd-BaSO₄; hydrogen / ethanol / 0.83 h / 20 °C

With Pd-BaSO₄; hydrogen; Dess-Martin periodane; In ethanol; dichloromethane;

DOI:10.1021/ol201561w

upstream raw materials:

3-chloro-4-methoxy-2-methoxymethoxy6-[(phenylmethoxy)methyl]-benzaldehyde

2,6-bis(methoxymethoxy)-α-[3-chloro-4-methoxy-2-methoxymethoxy-6-[(phenylmethoxy)-methyl]]-4-methyl-benzenemethanol

[2,6-bis(methoxymethoxy)-4-methylphenyl][3-chloro-4-methoxy-2-(methoxymethoxy)-6-[(phenylmethoxy)methyl]phenyl]-methanone

C₂₂H₂₅ClO₉

Downstream raw materials:

[2,6-bis(methoxymethoxy)-4-methylphenyl][3-chloro-4-methoxy-2-(methoxymethoxy)-6-[(phenylmethoxy)methyl]phenyl]-methanone

C₂₂H₂₇ClO₉

C₂₂H₂₇ClO₈

C₂₂H₂₅ClO₉