2-Furanacetyl chloride, alpha-oxo- (9CI)

Base Information

• Chemical Name: 2-Furanacetyl chloride, alpha-oxo- (9CI)
• CAS No.: 13938-68-6
• Molecular Formula: C6H3 Cl O3
• Molecular Weight: 158.541
• Mol file: 13938-68-6.mol

Synonyms:2-Furanglyoxyloylchloride (8CI)

Chemical Property of 2-Furanacetyl chloride, alpha-oxo- (9CI)

Chemical Property:

• PSA: 47.28000
• LogP: 1.22770

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Furanacetyl chloride, alpha-oxo- (9CI)

There total 2 articles about 2-Furanacetyl chloride, alpha-oxo- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

furan-2-yl-oxo-acetic acid (1467-70-5) → 2-chloro-1-(2-furyl)-2-oxo-1-ethanone (13938-68-6)

Guidance literature:

With Dichloromethyl methyl ether; at 20 - 50 ℃; Inert atmosphere;

DOI:10.1016/j.tet.2010.06.005

Reference yield:

furan (110-00-9) + oxalyl dichloride (79-37-8) → 2-chloro-1-(2-furyl)-2-oxo-1-ethanone (13938-68-6)

Guidance literature:

In diethyl ether; at 0 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.tetlet.2015.07.075

Reference yield: 34.0%

N-benzylindole (3377-71-7) + 2-chloro-1-(2-furyl)-2-oxo-1-ethanone (13938-68-6) → 1-(1-benzyl-1H-indol-3-yl)-2-(furan-2-yl)ethane-1,2-dione (1489263-03-7)

Guidance literature:

2-chloro-1-(2-furyl)-2-oxo-1-ethanone; With dmap; thionyl chloride; In dichloromethane; at 20 ℃; for 3h;

N-benzylindole; In dichloromethane; for 2h; Reflux;

DOI:10.1016/j.ejmech.2013.09.001

upstream raw materials:

furan-2-yl-oxo-acetic acid

furan

oxalyl dichloride

Downstream raw materials:

phenylmethyl (Z)-N-methoxy-2-furancarboximidate

C₁₅H₁₂F₃N₃O₄

1-(furan-2-yl)-4-phenylbut-3-yne-1,2-dione

1-(1-benzyl-1H-indol-3-yl)-2-(furan-2-yl)ethane-1,2-dione

Refernces

• 1、 Bonnin, Quentin,Chevalier, Arnaud,Dejouy, Garance,Michaudet, Cédric,Picquet, Michel,Renault, Kévin,Romieu, Anthony,Valverde, Ibai E.. "Fluorogenic Enzyme-Triggered Domino Reactions Producing Quinoxalin-2(1 H)-one-based Heterocycles". supporting information. p. 6494 - 6499. Retrieved 2020/09/02.
• 2、 Veale, Clinton G.L.. "A new synthesis of versatile indolyl-3-carbonylnitriles". . p. 5287 - 5290. Retrieved 2015/08/26.