1-[5-chloro-3-(4-hydroxypiperidin-1-yl)-2-methoxy-4-methylphenyl]ethanone

Base Information

Chemical Name:1-[5-chloro-3-(4-hydroxypiperidin-1-yl)-2-methoxy-4-methylphenyl]ethanone
CAS No.:1382995-36-9
Molecular Formula:C₁₅H₂₀ClNO₃
Molecular Weight:297.782
Hs Code.:

Synonyms:1-[5-chloro-3-(4-hydroxypiperidin-1-yl)-2-methoxy-4-methylphenyl]ethanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-[5-chloro-3-(4-hydroxypiperidin-1-yl)-2-methoxy-4-methylphenyl]ethanone

Chemical Property:

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Technology Process of 1-[5-chloro-3-(4-hydroxypiperidin-1-yl)-2-methoxy-4-methylphenyl]ethanone

There total 3 articles about 1-[5-chloro-3-(4-hydroxypiperidin-1-yl)-2-methoxy-4-methylphenyl]ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

: 5382-16-1
4-HYDROXYPIPERIDINE

: 1382995-35-8
1-(5-chloro-3-iodo-2-methoxy-4-methylphenyl)ethan-1-one

: 1382995-36-9
1-[5-chloro-3-(4-hydroxypiperidin-1-yl)-2-methoxy-4-methylphenyl]ethanone

Guidance literature:: With potassium phosphate; ethylene glycol; copper(l) iodide; In isopropyl alcohol; at 80 ℃;

Reference yield:

: 28480-70-8
5'-chloro-2'-hydroxy-4'-methyl acetophenone

: 1382995-36-9
1-[5-chloro-3-(4-hydroxypiperidin-1-yl)-2-methoxy-4-methylphenyl]ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: N-iodo-succinimide / acetic acid / 18 h / 20 °C

2: potassium carbonate / acetone / Reflux

3: potassium phosphate; ethylene glycol / copper(l) iodide / isopropyl alcohol / 80 °C

With potassium phosphate; N-iodo-succinimide; potassium carbonate; ethylene glycol; copper(l) iodide; In acetic acid; isopropyl alcohol; acetone;

Reference yield:

: 292144-86-6
1-(5-chloro-2-hydroxy-3-iodo-4-methylphenyl)ethan-1-one

: 1382995-36-9
1-[5-chloro-3-(4-hydroxypiperidin-1-yl)-2-methoxy-4-methylphenyl]ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetone / Reflux

2: potassium phosphate; ethylene glycol / copper(l) iodide / isopropyl alcohol / 80 °C

With potassium phosphate; potassium carbonate; ethylene glycol; copper(l) iodide; In isopropyl alcohol; acetone;