ethyl 2-[2,4-difluoro-6-(tetrahydropyrrole-1-yl)phenyl]-4-(2-chloro-4-fluorophenyl)-6-( tetrahydropyrrole-1-ylmethyl)-1,4-dihydropyrimidine-5-carboxylate

Base Information

Chemical Name:ethyl 2-[2,4-difluoro-6-(tetrahydropyrrole-1-yl)phenyl]-4-(2-chloro-4-fluorophenyl)-6-( tetrahydropyrrole-1-ylmethyl)-1,4-dihydropyrimidine-5-carboxylate
CAS No.:1197054-16-2
Molecular Formula:C₂₈H₃₀ClF₃N₄O₂
Molecular Weight:547.02
Hs Code.:

ethyl 2-[2,4-difluoro-6-(tetrahydropyrrole-1-yl)phenyl]-4-(2-chloro-4-fluorophenyl)-6-( tetrahydropyrrole-1-ylmethyl)-1,4-dihydropyrimidine-5-carboxylate

Synonyms:ethyl 2-[2,4-difluoro-6-(tetrahydropyrrole-1-yl)phenyl]-4-(2-chloro-4-fluorophenyl)-6-( tetrahydropyrrole-1-ylmethyl)-1,4-dihydropyrimidine-5-carboxylate

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Chemical Property of ethyl 2-[2,4-difluoro-6-(tetrahydropyrrole-1-yl)phenyl]-4-(2-chloro-4-fluorophenyl)-6-( tetrahydropyrrole-1-ylmethyl)-1,4-dihydropyrimidine-5-carboxylate

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Technology Process of ethyl 2-[2,4-difluoro-6-(tetrahydropyrrole-1-yl)phenyl]-4-(2-chloro-4-fluorophenyl)-6-( tetrahydropyrrole-1-ylmethyl)-1,4-dihydropyrimidine-5-carboxylate

There total 5 articles about ethyl 2-[2,4-difluoro-6-(tetrahydropyrrole-1-yl)phenyl]-4-(2-chloro-4-fluorophenyl)-6-( tetrahydropyrrole-1-ylmethyl)-1,4-dihydropyrimidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.8%

: 123-75-1
pyrrolidine

: 1197054-07-1
ethyl 2-(2,4,6-trifluorophenyl)-4-(2-chloro-4-fluorophenyl)-6-(chloromethyl)-1,4-dihydropyrimidine-5-carboxylate

: 1197054-16-2
ethyl 2-[2,4-difluoro-6-(tetrahydropyrrole-1-yl)phenyl]-4-(2-chloro-4-fluorophenyl)-6-( tetrahydropyrrole-1-ylmethyl)-1,4-dihydropyrimidine-5-carboxylate

Guidance literature:: potassium iodide; In tetrahydrofuran; at 20 ℃; for 28h; Inert atmosphere;

Reference yield: 25.8%

: 123-75-1
pyrrolidine

: C₂₁H₁₆Cl₂F₄N₂O₂

: 1197054-16-2
ethyl 2-[2,4-difluoro-6-(tetrahydropyrrole-1-yl)phenyl]-4-(2-chloro-4-fluorophenyl)-6-( tetrahydropyrrole-1-ylmethyl)-1,4-dihydropyrimidine-5-carboxylate

Guidance literature:: potassium iodide; In tetrahydrofuran; at 20 ℃; for 28h; Inert atmosphere;

Reference yield:

: 1005460-16-1
2,4,6-trifluorobenzimidamide acetate

: 1197054-16-2
ethyl 2-[2,4-difluoro-6-(tetrahydropyrrole-1-yl)phenyl]-4-(2-chloro-4-fluorophenyl)-6-( tetrahydropyrrole-1-ylmethyl)-1,4-dihydropyrimidine-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / ethanol / 72 h / Reflux

2: potassium iodide / tetrahydrofuran / 28 h / 20 °C / Inert atmosphere

With hydrogenchloride; potassium iodide; In tetrahydrofuran; ethanol;