methyl 2-(4-(4-chlorophenyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-hydroxyacetate

Base Information

Chemical Name:methyl 2-(4-(4-chlorophenyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-hydroxyacetate
CAS No.:1436855-55-8
Molecular Formula:C₁₉H₁₉ClN₂O₃
Molecular Weight:358.824
Hs Code.:

Synonyms:methyl 2-(4-(4-chlorophenyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-hydroxyacetate

Suppliers and Price of methyl 2-(4-(4-chlorophenyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-hydroxyacetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl 2-(4-(4-chlorophenyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-hydroxyacetate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl 2-(4-(4-chlorophenyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-hydroxyacetate

There total 12 articles about methyl 2-(4-(4-chlorophenyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-hydroxyacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 67-56-1
methanol

: 1436855-54-7
2-(4-(4-chlorophenyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-hydroxyacetic acid

: 1436855-55-8
methyl 2-(4-(4-chlorophenyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-hydroxyacetate

Guidance literature:: With sulfuric acid; for 18h; Reflux;

Reference yield:

: 1436855-50-3
(4-chloro-1-(4-methoxybenzyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)methanol

: 1436855-55-8
methyl 2-(4-(4-chlorophenyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-hydroxyacetate

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 6 h / 100 - 110 °C / Inert atmosphere

2: sulfur trioxide pyridine complex; triethylamine / dimethyl sulfoxide / 3 h / 10 - 25 °C

3: zinc(II) iodide / dichloromethane / 4 h / 0 - 25 °C / Inert atmosphere

4: hydrogenchloride / water / 18 h / 100 °C

5: sulfuric acid / 18 h / Reflux

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; sulfur trioxide pyridine complex; potassium carbonate; triethylamine; zinc(II) iodide; In dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; 1: |Suzuki Coupling;

Reference yield:

: 1436855-51-4
(4-(4-chlorophenyl)-1-(4-methoxybenzyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)methanol

: 1436855-55-8
methyl 2-(4-(4-chlorophenyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-hydroxyacetate

Guidance literature:: Multi-step reaction with 4 steps

1: sulfur trioxide pyridine complex; triethylamine / dimethyl sulfoxide / 3 h / 10 - 25 °C

2: zinc(II) iodide / dichloromethane / 4 h / 0 - 25 °C / Inert atmosphere

3: hydrogenchloride / water / 18 h / 100 °C

4: sulfuric acid / 18 h / Reflux

With hydrogenchloride; sulfuric acid; sulfur trioxide pyridine complex; triethylamine; zinc(II) iodide; In dichloromethane; water; dimethyl sulfoxide;