4-hydroxy-6-methoxymethoxy-2-[2-(4-methoxymethoxyphenyl)ethyl]-2,3-dihydro-isoindol-1-one

Base Information

Chemical Name:4-hydroxy-6-methoxymethoxy-2-[2-(4-methoxymethoxyphenyl)ethyl]-2,3-dihydro-isoindol-1-one
CAS No.:1425861-04-6
Molecular Formula:C₂₀H₂₃NO₆
Molecular Weight:373.406
Hs Code.:

Synonyms:4-hydroxy-6-methoxymethoxy-2-[2-(4-methoxymethoxyphenyl)ethyl]-2,3-dihydro-isoindol-1-one

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Chemical Property of 4-hydroxy-6-methoxymethoxy-2-[2-(4-methoxymethoxyphenyl)ethyl]-2,3-dihydro-isoindol-1-one

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Technology Process of 4-hydroxy-6-methoxymethoxy-2-[2-(4-methoxymethoxyphenyl)ethyl]-2,3-dihydro-isoindol-1-one

There total 4 articles about 4-hydroxy-6-methoxymethoxy-2-[2-(4-methoxymethoxyphenyl)ethyl]-2,3-dihydro-isoindol-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 2-[4-(methoxymethoxy)phenyl]ethan-1-amine

: 439600-45-0
2-formyl-3-hydroxy-5-methoxymethoxy-benzoic acid methyl ester

: 1425861-04-6
4-hydroxy-6-methoxymethoxy-2-[2-(4-methoxymethoxyphenyl)ethyl]-2,3-dihydro-isoindol-1-one

Guidance literature:: 2-[4-(methoxymethoxy)phenyl]ethan-1-amine; 2-formyl-3-hydroxy-5-methoxymethoxy-benzoic acid methyl ester; In methanol; for 1h;

With sodium tetrahydroborate; In methanol; at 0 - 20 ℃;
DOI:10.1055/s-0032-1317528

Reference yield:

: 16849-78-8
2-formyl-3,5-dihydroxybenzoic acid methyl ester

: 1425861-04-6
4-hydroxy-6-methoxymethoxy-2-[2-(4-methoxymethoxyphenyl)ethyl]-2,3-dihydro-isoindol-1-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / acetone / 12 h / 20 °C

2.1: methanol / 1 h

2.2: 0 - 20 °C

With potassium carbonate; In methanol; acetone;
DOI:10.1055/s-0032-1317528

Reference yield:

: 29655-46-7
N-benzyloxycarbonyl-2-(4-hydroxyphenyl)ethylamine

: 1425861-04-6
4-hydroxy-6-methoxymethoxy-2-[2-(4-methoxymethoxyphenyl)ethyl]-2,3-dihydro-isoindol-1-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0 - 20 °C

2.1: palladium 10% on activated carbon; hydrogen / methanol / 16 h

3.1: methanol / 1 h

3.2: 0 - 20 °C

With palladium 10% on activated carbon; hydrogen; sodium hydride; In methanol; N,N-dimethyl-formamide; mineral oil;
DOI:10.1055/s-0032-1317528