10-benzoyl-5-chloro-2-(4-fluoro-phenyl)-1-oxa-10a-aza-dicyclopenta[a,h]naphthalene-8,9-dicarboxylic acid dimethyl ester

Base Information

• Chemical Name: 10-benzoyl-5-chloro-2-(4-fluoro-phenyl)-1-oxa-10a-aza-dicyclopenta[a,h]naphthalene-8,9-dicarboxylic acid dimethyl ester
• CAS No.: 1436841-37-0
• Molecular Formula: C₃₁H₁₉ClFNO₆
• Molecular Weight: 555.946
• Mol file: 1436841-37-0.mol

Synonyms:10-benzoyl-5-chloro-2-(4-fluoro-phenyl)-1-oxa-10a-aza-dicyclopenta[a,h]naphthalene-8,9-dicarboxylic acid dimethyl ester

Chemical Property of 10-benzoyl-5-chloro-2-(4-fluoro-phenyl)-1-oxa-10a-aza-dicyclopenta[a,h]naphthalene-8,9-dicarboxylic acid dimethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 10-benzoyl-5-chloro-2-(4-fluoro-phenyl)-1-oxa-10a-aza-dicyclopenta[a,h]naphthalene-8,9-dicarboxylic acid dimethyl ester

There total 3 articles about 10-benzoyl-5-chloro-2-(4-fluoro-phenyl)-1-oxa-10a-aza-dicyclopenta[a,h]naphthalene-8,9-dicarboxylic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

5-chloro-9-(2-oxo-2-phenyl-ethyl)-2-(4-fluoro-phenyl)-furo[3,2-h]quinolin-9-ium bromide (1436840-94-6) + dimethyl acetylenedicarboxylate (762-42-5) → 10-benzoyl-5-chloro-2-(4-fluoro-phenyl)-1-oxa-10a-aza-dicyclopenta[a,h]naphthalene-8,9-dicarboxylic acid dimethyl ester (1436841-37-0)

Guidance literature:

With aluminum oxide; In chloroform; at 90 ℃; Microwave irradiation; Green chemistry;

DOI:10.1016/j.tetlet.2013.03.095

Reference yield:

α-bromoacetophenone (70-11-1) → 10-benzoyl-5-chloro-2-(4-fluoro-phenyl)-1-oxa-10a-aza-dicyclopenta[a,h]naphthalene-8,9-dicarboxylic acid dimethyl ester (1436841-37-0)

Guidance literature:

Multi-step reaction with 2 steps

1: acetonitrile / Reflux; Green chemistry

2: aluminum oxide / chloroform / 90 °C / Microwave irradiation; Green chemistry

With aluminum oxide; In chloroform; acetonitrile;

DOI:10.1016/j.tetlet.2013.03.095

Reference yield:

5-chloro-2-(4-fluorophenyl)furo[3,2-h]quinoline (1218818-89-3) → 10-benzoyl-5-chloro-2-(4-fluoro-phenyl)-1-oxa-10a-aza-dicyclopenta[a,h]naphthalene-8,9-dicarboxylic acid dimethyl ester (1436841-37-0)

Guidance literature:

Multi-step reaction with 2 steps

1: acetonitrile / Reflux; Green chemistry

2: aluminum oxide / chloroform / 90 °C / Microwave irradiation; Green chemistry

With aluminum oxide; In chloroform; acetonitrile;

DOI:10.1016/j.tetlet.2013.03.095

upstream raw materials:

5-chloro-2-(4-fluorophenyl)furo[3,2-h]quinoline

α-bromoacetophenone

5-chloro-9-(2-oxo-2-phenyl-ethyl)-2-(4-fluoro-phenyl)-furo[3,2-h]quinolin-9-ium bromide

dimethyl acetylenedicarboxylate