tert-butyl 6-((3,4-dichlorophenyl)hydroxymethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate

Base Information

Chemical Name:tert-butyl 6-((3,4-dichlorophenyl)hydroxymethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate
CAS No.:1370426-79-1
Molecular Formula:C₁₇H₂₁Cl₂NO₃
Molecular Weight:358.265
Hs Code.:

Synonyms:tert-butyl 6-((3,4-dichlorophenyl)hydroxymethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl 6-((3,4-dichlorophenyl)hydroxymethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate

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Technology Process of tert-butyl 6-((3,4-dichlorophenyl)hydroxymethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate

There total 1 articles about tert-butyl 6-((3,4-dichlorophenyl)hydroxymethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 912468-67-8
tert-butyl 6-formyl-3-azabicyclo[3.1.0]hexane-3-carboxylate

: 79175-35-2
3,4-dichlorophenylmagnesium bromide

: 1370426-79-1
tert-butyl 6-((3,4-dichlorophenyl)hydroxymethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate

Guidance literature:: In tetrahydrofuran; at -78 - 20 ℃; Inert atmosphere;

Reference yield: 86.0%

: 1370426-79-1
tert-butyl 6-((3,4-dichlorophenyl)hydroxymethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate

: 1370426-80-4
tert-butyl 6-(3,4-dichlorobenzoyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 1h; Inert atmosphere;

Reference yield:

: 1370426-79-1
tert-butyl 6-((3,4-dichlorophenyl)hydroxymethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate

: 1370426-81-5
tert-butyl 6-((3,4-dichlorophenyl)(hydroxyimino)methyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C / Inert atmosphere

2: pyridine; hydroxylamine hydrochloride / ethanol / 5 h / Inert atmosphere; Reflux

With pyridine; oxalyl dichloride; hydroxylamine hydrochloride; dimethyl sulfoxide; In ethanol; dichloromethane;