tert-butyl 6-((3,4-dichlorophenyl)(ethoxyimino)methyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate

Base Information

Chemical Name:tert-butyl 6-((3,4-dichlorophenyl)(ethoxyimino)methyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate
CAS No.:1370426-82-6
Molecular Formula:C₁₉H₂₄Cl₂N₂O₃
Molecular Weight:399.317
Hs Code.:

Synonyms:tert-butyl 6-((3,4-dichlorophenyl)(ethoxyimino)methyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate

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Chemical Property of tert-butyl 6-((3,4-dichlorophenyl)(ethoxyimino)methyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate

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Technology Process of tert-butyl 6-((3,4-dichlorophenyl)(ethoxyimino)methyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate

There total 5 articles about tert-butyl 6-((3,4-dichlorophenyl)(ethoxyimino)methyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1370426-81-5
tert-butyl 6-((3,4-dichlorophenyl)(hydroxyimino)methyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate

: 75-03-6
ethyl iodide

: 1370426-82-6
tert-butyl 6-((3,4-dichlorophenyl)(ethoxyimino)methyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate

Guidance literature:: tert-butyl 6-((3,4-dichlorophenyl)(hydroxyimino)methyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.5h; Inert atmosphere;

ethyl iodide; In N,N-dimethyl-formamide; mineral oil; at 20 ℃;

Reference yield:

: 1370426-79-1
tert-butyl 6-((3,4-dichlorophenyl)hydroxymethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate

: 1370426-82-6
tert-butyl 6-((3,4-dichlorophenyl)(ethoxyimino)methyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C / Inert atmosphere

2.1: pyridine; hydroxylamine hydrochloride / ethanol / 5 h / Inert atmosphere; Reflux

3.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

3.2: 20 °C

With pyridine; oxalyl dichloride; hydroxylamine hydrochloride; sodium hydride; dimethyl sulfoxide; In ethanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1370426-80-4
tert-butyl 6-(3,4-dichlorobenzoyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate

: 1370426-82-6
tert-butyl 6-((3,4-dichlorophenyl)(ethoxyimino)methyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine; hydroxylamine hydrochloride / ethanol / 5 h / Inert atmosphere; Reflux

2.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

2.2: 20 °C

With pyridine; hydroxylamine hydrochloride; sodium hydride; In ethanol; N,N-dimethyl-formamide; mineral oil;