methyl 1-{4-(3,4-dichlorophenylcarbonylamino)phenylcarbonyl}isoquinolin-4-ylacetate

Base Information

• Chemical Name: methyl 1-{4-(3,4-dichlorophenylcarbonylamino)phenylcarbonyl}isoquinolin-4-ylacetate
• CAS No.: 1233249-40-5
• Molecular Formula: C₂₆H₁₈Cl₂N₂O₄
• Molecular Weight: 493.346
• Mol file: 1233249-40-5.mol

Synonyms:methyl 1-{4-(3,4-dichlorophenylcarbonylamino)phenylcarbonyl}isoquinolin-4-ylacetate

Chemical Property of methyl 1-{4-(3,4-dichlorophenylcarbonylamino)phenylcarbonyl}isoquinolin-4-ylacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 1-{4-(3,4-dichlorophenylcarbonylamino)phenylcarbonyl}isoquinolin-4-ylacetate

There total 9 articles about methyl 1-{4-(3,4-dichlorophenylcarbonylamino)phenylcarbonyl}isoquinolin-4-ylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 1-[4-(aminophenyl)carbonyl]isoquinolin-4-ylacetate (1233249-39-2) + 3,4-dichlorobenzoyl chloride (3024-72-4) → methyl 1-{4-(3,4-dichlorophenylcarbonylamino)phenylcarbonyl}isoquinolin-4-ylacetate (1233249-40-5)

Guidance literature:

With pyridine; at 20 ℃; for 13.5h; Cooling with ice;

Reference yield:

p-aminophenylacetonitrile (3544-25-0) → methyl 1-{4-(3,4-dichlorophenylcarbonylamino)phenylcarbonyl}isoquinolin-4-ylacetate (1233249-40-5)

Guidance literature:

Multi-step reaction with 6 steps

1.1: ethanol / 2 h / 20 °C

2.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / Cooling with ice

2.2: 2.5 h / 20 °C / Cooling with ice

2.3: 17 h / 20 °C

3.1: sodium hydroxide; water / methanol / 18 h / 20 - 35 °C

4.1: oxalyl dichloride / chloroform / 3.5 h / 20 °C / Cooling with ice

4.2: 2 h / Cooling with ice

5.1: trifluoroacetic acid / chloroform / 1.5 h / 20 °C / Cooling with ice

6.1: pyridine / 13.5 h / 20 °C / Cooling with ice

With pyridine; oxalyl dichloride; water; sodium hexamethyldisilazane; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; chloroform;

Reference yield:

2-[1-[4-[(2-methylpropan-2-yl)oxycarbonylamino]benzoyl]isoquinolin-4-yl]acetic acid (1233249-38-1) → methyl 1-{4-(3,4-dichlorophenylcarbonylamino)phenylcarbonyl}isoquinolin-4-ylacetate (1233249-40-5)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / chloroform / 1.5 h / 20 °C / Cooling with ice

2: pyridine / 13.5 h / 20 °C / Cooling with ice

With pyridine; trifluoroacetic acid; In chloroform;

upstream raw materials:

methyl 1-[4-(aminophenyl)carbonyl]isoquinolin-4-ylacetate

3,4-dichlorobenzoyl chloride

p-aminophenylacetonitrile

1-{4-(tert-butoxycarbonylamino)phenylcarbonyl}isoquinolin-4-ylcarboxylic acid

Downstream raw materials:

TAS⁽⁷⁶³⁾P₀₃₇₇

2-[1-[4-[(3,4-Dichlorobenzoyl)-methylamino]benzoyl]isoquinolin-4-yl]acetic acid