2-[1-[4-[(3,4-Dichlorobenzoyl)-methylamino]benzoyl]isoquinolin-4-yl]acetic acid

Base Information

Chemical Name:2-[1-[4-[(3,4-Dichlorobenzoyl)-methylamino]benzoyl]isoquinolin-4-yl]acetic acid
CAS No.:1233248-04-8
Molecular Formula:C₂₆H₁₈Cl₂N₂O₄
Molecular Weight:493.346
Hs Code.:

Synonyms:2-[1-[4-[(3,4-Dichlorobenzoyl)-methylamino]benzoyl]isoquinolin-4-yl]acetic acid

Suppliers and Price of 2-[1-[4-[(3,4-Dichlorobenzoyl)-methylamino]benzoyl]isoquinolin-4-yl]acetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-[1-[4-[(3,4-Dichlorobenzoyl)-methylamino]benzoyl]isoquinolin-4-yl]acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-[1-[4-[(3,4-Dichlorobenzoyl)-methylamino]benzoyl]isoquinolin-4-yl]acetic acid

There total 13 articles about 2-[1-[4-[(3,4-Dichlorobenzoyl)-methylamino]benzoyl]isoquinolin-4-yl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 1233246-60-0
TAS⁽⁷⁶³⁾P₀₃₇₇

: 74-88-4
methyl iodide

: 1233248-04-8
2-[1-[4-[(3,4-Dichlorobenzoyl)-methylamino]benzoyl]isoquinolin-4-yl]acetic acid

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 20 ℃;
DOI:10.1016/j.bmcl.2012.03.009

Reference yield:

: 67-56-1
methanol

: 1233246-60-0
TAS⁽⁷⁶³⁾P₀₃₇₇

: 1233248-04-8
2-[1-[4-[(3,4-Dichlorobenzoyl)-methylamino]benzoyl]isoquinolin-4-yl]acetic acid

Guidance literature:: TAS⁽⁷⁶³⁾P₀₃₇₇; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 1h; Cooling with ice;

methanol; With methyl iodide; In tetrahydrofuran; mineral oil; at 20 ℃; for 3h;

Reference yield:

: 1233249-37-0
1-{4-(tert-butoxycarbonylamino)phenylcarbonyl}isoquinolin-4-ylcarboxylic acid

: 1233248-04-8
2-[1-[4-[(3,4-Dichlorobenzoyl)-methylamino]benzoyl]isoquinolin-4-yl]acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: oxalyl dichloride / chloroform / 3.5 h / 20 °C / Cooling with ice

1.2: 2 h / Cooling with ice

2.1: trifluoroacetic acid / chloroform / 1.5 h / 20 °C / Cooling with ice

3.1: pyridine / 13.5 h / 20 °C / Cooling with ice

4.1: sodium hydroxide; water / tetrahydrofuran; methanol / 0.5 h / 20 °C / Cooling with ice

5.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C / Cooling with ice

5.2: 3 h / 20 °C

With pyridine; oxalyl dichloride; water; sodium hydride; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; chloroform; mineral oil;