acetic acid 4-(3-chloro-4-fluoro-phenylamino)-6-methoxy-quinazolin-7-yl ester

Base Information

Chemical Name:acetic acid 4-(3-chloro-4-fluoro-phenylamino)-6-methoxy-quinazolin-7-yl ester
CAS No.:869475-50-3
Molecular Formula:C₁₇H₁₃ClFN₃O₃
Molecular Weight:361.76
Hs Code.:

Synonyms:acetic acid 4-(3-chloro-4-fluoro-phenylamino)-6-methoxy-quinazolin-7-yl ester

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Chemical Property of acetic acid 4-(3-chloro-4-fluoro-phenylamino)-6-methoxy-quinazolin-7-yl ester

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Technology Process of acetic acid 4-(3-chloro-4-fluoro-phenylamino)-6-methoxy-quinazolin-7-yl ester

There total 4 articles about acetic acid 4-(3-chloro-4-fluoro-phenylamino)-6-methoxy-quinazolin-7-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 179688-03-0
4-chloro-6-methoxyquinazolin-7-yl acetate

: 367-21-5
3-chloro-4-fluorophenylamine

: 869475-50-3
acetic acid 4-(3-chloro-4-fluoro-phenylamino)-6-methoxy-quinazolin-7-yl ester

Guidance literature:: With isopropyl alcohol; Heating;
DOI:10.1016/j.tetlet.2005.08.123

Reference yield:

: 162012-72-8
7-hydroxy-6-methoxy-3,4-dihydroquinazolin-4-one

: 869475-50-3
acetic acid 4-(3-chloro-4-fluoro-phenylamino)-6-methoxy-quinazolin-7-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / pyridine / 1 h / Heating

2: 69 percent / SOCl₂ / 1.5 h / Heating

3: 91 percent / i-PrOH / Heating

With pyridine; thionyl chloride; isopropyl alcohol;
DOI:10.1016/j.tetlet.2005.08.123

Reference yield:

: 179688-02-9
7-acetoxy-6-methoxy-3,4-dihydroquinazolin-4-one

: 869475-50-3
acetic acid 4-(3-chloro-4-fluoro-phenylamino)-6-methoxy-quinazolin-7-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 69 percent / SOCl₂ / 1.5 h / Heating

2: 91 percent / i-PrOH / Heating

With thionyl chloride; isopropyl alcohol;
DOI:10.1016/j.tetlet.2005.08.123