3-(2-cyanoethyl) 4-(3-chlorophenyl)-2-methyl-6-trifluoromethyl-1,4-dihydropyridine-3,5-dicarboxylate

Base Information

Chemical Name:3-(2-cyanoethyl) 4-(3-chlorophenyl)-2-methyl-6-trifluoromethyl-1,4-dihydropyridine-3,5-dicarboxylate
CAS No.:314776-26-6
Molecular Formula:C₁₈H₁₄ClF₃N₂O₄
Molecular Weight:414.768
Hs Code.:

Synonyms:3-(2-cyanoethyl) 4-(3-chlorophenyl)-2-methyl-6-trifluoromethyl-1,4-dihydropyridine-3,5-dicarboxylate

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Chemical Property of 3-(2-cyanoethyl) 4-(3-chlorophenyl)-2-methyl-6-trifluoromethyl-1,4-dihydropyridine-3,5-dicarboxylate

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Technology Process of 3-(2-cyanoethyl) 4-(3-chlorophenyl)-2-methyl-6-trifluoromethyl-1,4-dihydropyridine-3,5-dicarboxylate

There total 4 articles about 3-(2-cyanoethyl) 4-(3-chlorophenyl)-2-methyl-6-trifluoromethyl-1,4-dihydropyridine-3,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 314776-25-5
5-benzyl 3-(2-cyanoethyl) 4-(3-chlorophenyl)-2-methyl-6-trifluoromethyl-1,4-dihydropyridine-3,5-dicarboxylate

: 314776-26-6
3-(2-cyanoethyl) 4-(3-chlorophenyl)-2-methyl-6-trifluoromethyl-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol;
DOI:10.1016/j.bmcl.2005.11.021

Reference yield:

: 874179-67-6
4-(3-chloro-phenyl)-2-hydroxy-6-methyl-2-trifluoromethyl-1,2,3,4-tetrahydro-pyridine-3,5-dicarboxylic acid 3-benzyl ester 5-(2-cyano-ethyl) ester

: 314776-26-6
3-(2-cyanoethyl) 4-(3-chlorophenyl)-2-methyl-6-trifluoromethyl-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: POCl₃; pyridine/SiO₂ / 1,2-dichloro-ethane

2: H₂ / Pd/C / ethanol

With pyridine; hydrogen; silica gel; trichlorophosphate; palladium on activated charcoal; In ethanol; 1,2-dichloro-ethane;
DOI:10.1016/j.bmcl.2005.11.021

Reference yield:

: 65193-87-5
2-cyanoethylacetoacetate

: 314776-26-6
3-(2-cyanoethyl) 4-(3-chlorophenyl)-2-methyl-6-trifluoromethyl-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: AcONH₄ / propan-2-ol

2: propan-2-ol

3: POCl₃; pyridine/SiO₂ / 1,2-dichloro-ethane

4: H₂ / Pd/C / ethanol

With pyridine; ammonium acetate; hydrogen; silica gel; trichlorophosphate; palladium on activated charcoal; In ethanol; 1,2-dichloro-ethane; isopropyl alcohol; 2: Hantzsch synthesis;
DOI:10.1016/j.bmcl.2005.11.021