5-benzyl 3-(2-cyanoethyl) 4-(3-chlorophenyl)-2-methyl-6-trifluoromethyl-1,4-dihydropyridine-3,5-dicarboxylate

Base Information

• Chemical Name: 5-benzyl 3-(2-cyanoethyl) 4-(3-chlorophenyl)-2-methyl-6-trifluoromethyl-1,4-dihydropyridine-3,5-dicarboxylate
• CAS No.: 314776-25-5
• Molecular Formula: C₂₅H₂₀ClF₃N₂O₄
• Molecular Weight: 504.893
• Mol file: 314776-25-5.mol

Synonyms:5-benzyl 3-(2-cyanoethyl) 4-(3-chlorophenyl)-2-methyl-6-trifluoromethyl-1,4-dihydropyridine-3,5-dicarboxylate

Chemical Property of 5-benzyl 3-(2-cyanoethyl) 4-(3-chlorophenyl)-2-methyl-6-trifluoromethyl-1,4-dihydropyridine-3,5-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-benzyl 3-(2-cyanoethyl) 4-(3-chlorophenyl)-2-methyl-6-trifluoromethyl-1,4-dihydropyridine-3,5-dicarboxylate

There total 6 articles about 5-benzyl 3-(2-cyanoethyl) 4-(3-chlorophenyl)-2-methyl-6-trifluoromethyl-1,4-dihydropyridine-3,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl 4,4,4-trifluoroacetoacetate (83097-87-4) + m-Chlorobenzaldehyde (587-04-2) + (Z)-3-Amino-but-2-enoic acid 2-cyano-ethyl ester (193539-61-6) → 5-benzyl 3-(2-cyanoethyl) 4-(3-chlorophenyl)-2-methyl-6-trifluoromethyl-1,4-dihydropyridine-3,5-dicarboxylate (314776-25-5)

Guidance literature:

With pyridine; trichlorophosphate; In 1,2-dichloro-ethane;

Reference yield:

4-(3-chloro-phenyl)-2-hydroxy-6-methyl-2-trifluoromethyl-1,2,3,4-tetrahydro-pyridine-3,5-dicarboxylic acid 3-benzyl ester 5-(2-cyano-ethyl) ester (874179-67-6) → 5-benzyl 3-(2-cyanoethyl) 4-(3-chlorophenyl)-2-methyl-6-trifluoromethyl-1,4-dihydropyridine-3,5-dicarboxylate (314776-25-5)

Guidance literature:

With pyridine; silica gel; trichlorophosphate; In 1,2-dichloro-ethane;

DOI:10.1016/j.bmcl.2005.11.021

Reference yield:

2-cyanoethylacetoacetate (65193-87-5) → 5-benzyl 3-(2-cyanoethyl) 4-(3-chlorophenyl)-2-methyl-6-trifluoromethyl-1,4-dihydropyridine-3,5-dicarboxylate (314776-25-5)

Guidance literature:

Multi-step reaction with 3 steps

1: AcONH₄ / propan-2-ol

2: propan-2-ol

3: POCl₃; pyridine/SiO₂ / 1,2-dichloro-ethane

With pyridine; ammonium acetate; silica gel; trichlorophosphate; In 1,2-dichloro-ethane; isopropyl alcohol; 2: Hantzsch synthesis;

DOI:10.1016/j.bmcl.2005.11.021

upstream raw materials:

4-(3-chloro-phenyl)-2-hydroxy-6-methyl-2-trifluoromethyl-1,2,3,4-tetrahydro-pyridine-3,5-dicarboxylic acid 3-benzyl ester 5-(2-cyano-ethyl) ester

2-cyanoethylacetoacetate

benzyl 4,4,4-trifluoroacetoacetate

(Z)-3-Amino-but-2-enoic acid 2-cyano-ethyl ester

Downstream raw materials:

3-(2-cyanoethyl) 5-(3,3-diphenylpropyl) 4-(3-chlorophenyl)-2-methyl-6-trifluoromethyl-1,4-dihydropyridine-3,5-dicarboxylate

3-(2-cyanoethyl) 4-(3-chlorophenyl)-2-methyl-6-trifluoromethyl-1,4-dihydropyridine-3,5-dicarboxylate