4-(3-chloro-phenyl)-2-hydroxy-6-methyl-2-trifluoromethyl-1,2,3,4-tetrahydro-pyridine-3,5-dicarboxylic acid 3-benzyl ester 5-(2-cyano-ethyl) ester

Base Information

Chemical Name:4-(3-chloro-phenyl)-2-hydroxy-6-methyl-2-trifluoromethyl-1,2,3,4-tetrahydro-pyridine-3,5-dicarboxylic acid 3-benzyl ester 5-(2-cyano-ethyl) ester
CAS No.:874179-67-6
Molecular Formula:C₂₅H₂₂ClF₃N₂O₅
Molecular Weight:522.908
Hs Code.:

4-(3-chloro-phenyl)-2-hydroxy-6-methyl-2-trifluoromethyl-1,2,3,4-tetrahydro-pyridine-3,5-dicarboxylic acid 3-benzyl ester 5-(2-cyano-ethyl) ester

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Chemical Property of 4-(3-chloro-phenyl)-2-hydroxy-6-methyl-2-trifluoromethyl-1,2,3,4-tetrahydro-pyridine-3,5-dicarboxylic acid 3-benzyl ester 5-(2-cyano-ethyl) ester

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Technology Process of 4-(3-chloro-phenyl)-2-hydroxy-6-methyl-2-trifluoromethyl-1,2,3,4-tetrahydro-pyridine-3,5-dicarboxylic acid 3-benzyl ester 5-(2-cyano-ethyl) ester

There total 3 articles about 4-(3-chloro-phenyl)-2-hydroxy-6-methyl-2-trifluoromethyl-1,2,3,4-tetrahydro-pyridine-3,5-dicarboxylic acid 3-benzyl ester 5-(2-cyano-ethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 65193-87-5
2-cyanoethylacetoacetate

: 874179-67-6
4-(3-chloro-phenyl)-2-hydroxy-6-methyl-2-trifluoromethyl-1,2,3,4-tetrahydro-pyridine-3,5-dicarboxylic acid 3-benzyl ester 5-(2-cyano-ethyl) ester

Guidance literature:: Multi-step reaction with 2 steps

1: AcONH₄ / propan-2-ol

2: propan-2-ol

With ammonium acetate; In isopropyl alcohol; 2: Hantzsch synthesis;
DOI:10.1016/j.bmcl.2005.11.021

Reference yield:

: 100-51-6,185532-71-2
benzyl alcohol

: 874179-67-6
4-(3-chloro-phenyl)-2-hydroxy-6-methyl-2-trifluoromethyl-1,2,3,4-tetrahydro-pyridine-3,5-dicarboxylic acid 3-benzyl ester 5-(2-cyano-ethyl) ester

Guidance literature:: Multi-step reaction with 2 steps

1: toluene

2: propan-2-ol

In isopropyl alcohol; toluene; 2: Hantzsch synthesis;
DOI:10.1016/j.bmcl.2005.11.021