3-(2-cyanoethyl) 5-(3,3-diphenylpropyl) 4-(3-chlorophenyl)-2-methyl-6-trifluoromethyl-1,4-dihydropyridine-3,5-dicarboxylate

Base Information

Chemical Name:3-(2-cyanoethyl) 5-(3,3-diphenylpropyl) 4-(3-chlorophenyl)-2-methyl-6-trifluoromethyl-1,4-dihydropyridine-3,5-dicarboxylate
CAS No.:314776-27-7
Molecular Formula:C₃₃H₂₈ClF₃N₂O₄
Molecular Weight:609.045
Hs Code.:

Synonyms:3-(2-cyanoethyl) 5-(3,3-diphenylpropyl) 4-(3-chlorophenyl)-2-methyl-6-trifluoromethyl-1,4-dihydropyridine-3,5-dicarboxylate

Suppliers and Price of 3-(2-cyanoethyl) 5-(3,3-diphenylpropyl) 4-(3-chlorophenyl)-2-methyl-6-trifluoromethyl-1,4-dihydropyridine-3,5-dicarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-(2-cyanoethyl) 5-(3,3-diphenylpropyl) 4-(3-chlorophenyl)-2-methyl-6-trifluoromethyl-1,4-dihydropyridine-3,5-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-(2-cyanoethyl) 5-(3,3-diphenylpropyl) 4-(3-chlorophenyl)-2-methyl-6-trifluoromethyl-1,4-dihydropyridine-3,5-dicarboxylate

There total 6 articles about 3-(2-cyanoethyl) 5-(3,3-diphenylpropyl) 4-(3-chlorophenyl)-2-methyl-6-trifluoromethyl-1,4-dihydropyridine-3,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 314776-26-6
3-(2-cyanoethyl) 4-(3-chlorophenyl)-2-methyl-6-trifluoromethyl-1,4-dihydropyridine-3,5-dicarboxylate

: WSC_.HCl

: 20017-67-8
3,3-diphenylpropan-1-ol

: 314776-27-7
3-(2-cyanoethyl) 5-(3,3-diphenylpropyl) 4-(3-chlorophenyl)-2-methyl-6-trifluoromethyl-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:: With dmap; triethylamine; In dichloromethane; water;

Reference yield:

: 874179-67-6
4-(3-chloro-phenyl)-2-hydroxy-6-methyl-2-trifluoromethyl-1,2,3,4-tetrahydro-pyridine-3,5-dicarboxylic acid 3-benzyl ester 5-(2-cyano-ethyl) ester

: 314776-27-7
3-(2-cyanoethyl) 5-(3,3-diphenylpropyl) 4-(3-chlorophenyl)-2-methyl-6-trifluoromethyl-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: POCl₃; pyridine/SiO₂ / 1,2-dichloro-ethane

2: H₂ / Pd/C / ethanol

3: EDC; DMAP; Et₃N / CH₂Cl₂

With pyridine; dmap; hydrogen; silica gel; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; trichlorophosphate; palladium on activated charcoal; In ethanol; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1016/j.bmcl.2005.11.021

Reference yield:

: 314776-25-5
5-benzyl 3-(2-cyanoethyl) 4-(3-chlorophenyl)-2-methyl-6-trifluoromethyl-1,4-dihydropyridine-3,5-dicarboxylate

: 314776-27-7
3-(2-cyanoethyl) 5-(3,3-diphenylpropyl) 4-(3-chlorophenyl)-2-methyl-6-trifluoromethyl-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / Pd/C / ethanol

2: EDC; DMAP; Et₃N / CH₂Cl₂

With dmap; hydrogen; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2005.11.021