ethyl 2-(4-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)benzo[d]thiazole-6-carboxylate

Base Information

Chemical Name:ethyl 2-(4-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)benzo[d]thiazole-6-carboxylate
CAS No.:1383739-48-7
Molecular Formula:C₂₉H₂₈F₃N₃O₅S
Molecular Weight:587.62
Hs Code.:

Synonyms:ethyl 2-(4-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)benzo[d]thiazole-6-carboxylate

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Chemical Property of ethyl 2-(4-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)benzo[d]thiazole-6-carboxylate

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Technology Process of ethyl 2-(4-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)benzo[d]thiazole-6-carboxylate

There total 10 articles about ethyl 2-(4-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)benzo[d]thiazole-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1383740-03-1
5-cyclopropyl-4-((piperidin-4-yloxy)methyl)-3-(2-(trifluoromethoxy)phenyl)isoxazole

: 78485-37-7
6-aethoxycarbonyl-2-chlorbenzothiazol

: 1383739-48-7
ethyl 2-(4-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)benzo[d]thiazole-6-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; at 60 ℃;

Reference yield:

: 5-cyclopropyl-4-((piperidin-4-yloxy)methyl)-3-(2-(trifluoromethoxy)phenyl)isoxazole trifluoroacetate

: 78485-37-7
6-aethoxycarbonyl-2-chlorbenzothiazol

: 1383739-48-7
ethyl 2-(4-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)benzo[d]thiazole-6-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl acetamide; at 60 ℃; for 20h;
DOI:10.1021/acs.jmedchem.7b00907

Reference yield:

: 94651-33-9
2-(trifluoromethoxy)benzaldehyde

: 1383739-48-7
ethyl 2-(4-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)benzo[d]thiazole-6-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1: hydroxylamine hydrochloride; sodium hydroxide / ethanol; water / 1 h / 20 °C

2: N-chloro-succinimide / N,N-dimethyl-formamide / 1 h / 20 - 25 °C

3: potassium carbonate / tetrahydrofuran / 6 h / -5 - 35 °C

4: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / -10 °C / Inert atmosphere

5: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h

6: potassium tert-butylate; 18-crown-6 ether / tetrahydrofuran / Inert atmosphere

7: trifluoroacetic acid / dichloromethane / 1 h

8: N-ethyl-N,N-diisopropylamine / 60 °C

With N-chloro-succinimide; lithium aluminium tetrahydride; 18-crown-6 ether; carbon tetrabromide; hydroxylamine hydrochloride; potassium tert-butylate; potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;