Technology Process of C32H51FN4O5
There total 8 articles about C32H51FN4O5 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(S)-tert-butyl 2-amino-3-cyclohexylpropyl(methyl)carbamate; 4-Nitrophenyl chloroformate;
With
sodium hydrogencarbonate;
In
acetonitrile;
for 4h;
(S)-5-fluoro-3-(4-methoxybutyl)-3-(2-(methylamino)ethyl)isoindolin-1-one;
With
N-ethyl-N,N-diisopropylamine;
In
acetonitrile;
for 1h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 20 °C
2.1: dichloromethane / 4 h / 20 °C
2.2: 1.5 h / 0 - 20 °C
3.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.5 h / -78 °C
3.2: 4 h / -20 - 0 °C
4.1: titanium ethoxide / 1,4-dioxane / 72 h / 90 °C / sealed tube
5.1: tetrahydrofuran; toluene / 4 h / 100 °C
5.2: 6 h / 100 °C / sealed tube
6.1: sodium hydrogencarbonate / acetonitrile / 4 h
6.2: 1 h
With
oxalyl dichloride; tert.-butyl lithium; sodium hydrogencarbonate;
N,N-dimethyl-formamide;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; toluene; acetonitrile; pentane;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: tetrahydrofuran / 4 h / Heating / reflux
2.1: tetrahydrofuran; toluene / 4 h / 100 °C
2.2: 6 h / 100 °C / sealed tube
3.1: sodium hydrogencarbonate / acetonitrile / 4 h
3.2: 1 h
With
sodium hydrogencarbonate;
In
tetrahydrofuran; toluene; acetonitrile;
