1-(2-cyclohexylamino-pyridin-4-yl)-2-(3,4-dichloro-phenyl)-1H-benzoimidazol-5-ol

Base Information

Chemical Name:1-(2-cyclohexylamino-pyridin-4-yl)-2-(3,4-dichloro-phenyl)-1H-benzoimidazol-5-ol
CAS No.:1428958-87-5
Molecular Formula:C₂₄H₂₂Cl₂N₄O
Molecular Weight:453.371
Hs Code.:

Synonyms:1-(2-cyclohexylamino-pyridin-4-yl)-2-(3,4-dichloro-phenyl)-1H-benzoimidazol-5-ol

Suppliers and Price of 1-(2-cyclohexylamino-pyridin-4-yl)-2-(3,4-dichloro-phenyl)-1H-benzoimidazol-5-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(2-cyclohexylamino-pyridin-4-yl)-2-(3,4-dichloro-phenyl)-1H-benzoimidazol-5-ol

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-(2-cyclohexylamino-pyridin-4-yl)-2-(3,4-dichloro-phenyl)-1H-benzoimidazol-5-ol

There total 7 articles about 1-(2-cyclohexylamino-pyridin-4-yl)-2-(3,4-dichloro-phenyl)-1H-benzoimidazol-5-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1428958-79-5
cyclohexyl-{4-[2-(3,4-dichloro-phenyl)-5-methoxy-benzoimidazol-1-yl]-pyridin-2-yl}-amine

: 1428958-87-5
1-(2-cyclohexylamino-pyridin-4-yl)-2-(3,4-dichloro-phenyl)-1H-benzoimidazol-5-ol

Guidance literature:: cyclohexyl-{4-[2-(3,4-dichloro-phenyl)-5-methoxy-benzoimidazol-1-yl]-pyridin-2-yl}-amine; With boron tribromide; In dichloromethane; at -78 - 20 ℃; for 3h;

With methanol; In dichloromethane; at 0 - 20 ℃; for 1h;
DOI:10.1016/j.bmc.2013.02.021

Reference yield:

: 14432-16-7
2-chloro-4-nitropyridine-N-oxide

: 1428958-87-5
1-(2-cyclohexylamino-pyridin-4-yl)-2-(3,4-dichloro-phenyl)-1H-benzoimidazol-5-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: ethanol / 13 h / 80 °C

2.1: hydrogen / methanol / 9 h / 20 °C

3.1: palladium diacetate; BINAP; potassium phosphate / toluene / 3 h / 130 °C / Inert atmosphere

4.1: hydrogen; palladium on activated charcoal / methanol / 0.5 h / 20 °C

5.1: dihydrogen peroxide; ammonium cerium (IV) nitrate / ethanol / 8 h / 50 °C

6.1: boron tribromide / dichloromethane / 3 h / -78 - 20 °C

6.2: 1 h / 0 - 20 °C

With potassium phosphate; ammonium cerium (IV) nitrate; BINAP; palladium on activated charcoal; hydrogen; dihydrogen peroxide; palladium diacetate; boron tribromide; In methanol; ethanol; dichloromethane; toluene;
DOI:10.1016/j.bmc.2013.02.021

Reference yield:

: 108-91-8,157973-60-9
cyclohexylamine

: 1428958-87-5
1-(2-cyclohexylamino-pyridin-4-yl)-2-(3,4-dichloro-phenyl)-1H-benzoimidazol-5-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: ethanol / 13 h / 80 °C

2.1: hydrogen / methanol / 9 h / 20 °C

3.1: palladium diacetate; BINAP; potassium phosphate / toluene / 3 h / 130 °C / Inert atmosphere

4.1: hydrogen; palladium on activated charcoal / methanol / 0.5 h / 20 °C

5.1: dihydrogen peroxide; ammonium cerium (IV) nitrate / ethanol / 8 h / 50 °C

6.1: boron tribromide / dichloromethane / 3 h / -78 - 20 °C

6.2: 1 h / 0 - 20 °C

With potassium phosphate; ammonium cerium (IV) nitrate; BINAP; palladium on activated charcoal; hydrogen; dihydrogen peroxide; palladium diacetate; boron tribromide; In methanol; ethanol; dichloromethane; toluene;
DOI:10.1016/j.bmc.2013.02.021