cyclohexyl-{4-[2-(3,4-dichloro-phenyl)-5-methoxy-benzoimidazol-1-yl]-pyridin-2-yl}-amine

Base Information

Chemical Name:cyclohexyl-{4-[2-(3,4-dichloro-phenyl)-5-methoxy-benzoimidazol-1-yl]-pyridin-2-yl}-amine
CAS No.:1428958-79-5
Molecular Formula:C₂₅H₂₄Cl₂N₄O
Molecular Weight:467.398
Hs Code.:

Synonyms:cyclohexyl-{4-[2-(3,4-dichloro-phenyl)-5-methoxy-benzoimidazol-1-yl]-pyridin-2-yl}-amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of cyclohexyl-{4-[2-(3,4-dichloro-phenyl)-5-methoxy-benzoimidazol-1-yl]-pyridin-2-yl}-amine

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Technology Process of cyclohexyl-{4-[2-(3,4-dichloro-phenyl)-5-methoxy-benzoimidazol-1-yl]-pyridin-2-yl}-amine

There total 6 articles about cyclohexyl-{4-[2-(3,4-dichloro-phenyl)-5-methoxy-benzoimidazol-1-yl]-pyridin-2-yl}-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1428958-65-9
N⁴-(2-amino-4-methoxy-phenyl)-N²-cyclohexyl-pyridine-2,4-diamine

: 6287-38-3
3,4-dichlorobenzaldehyde

: 1428958-79-5
cyclohexyl-{4-[2-(3,4-dichloro-phenyl)-5-methoxy-benzoimidazol-1-yl]-pyridin-2-yl}-amine

Guidance literature:: With ammonium cerium (IV) nitrate; dihydrogen peroxide; In ethanol; at 50 ℃; for 8h;
DOI:10.1016/j.bmc.2013.02.021

Reference yield:

: 14432-16-7
2-chloro-4-nitropyridine-N-oxide

: 1428958-79-5
cyclohexyl-{4-[2-(3,4-dichloro-phenyl)-5-methoxy-benzoimidazol-1-yl]-pyridin-2-yl}-amine

Guidance literature:: Multi-step reaction with 5 steps

1: ethanol / 13 h / 80 °C

2: hydrogen / methanol / 9 h / 20 °C

3: palladium diacetate; BINAP; potassium phosphate / toluene / 3 h / 130 °C / Inert atmosphere

4: hydrogen; palladium on activated charcoal / methanol / 0.5 h / 20 °C

5: dihydrogen peroxide; ammonium cerium (IV) nitrate / ethanol / 8 h / 50 °C

With potassium phosphate; ammonium cerium (IV) nitrate; BINAP; palladium on activated charcoal; hydrogen; dihydrogen peroxide; palladium diacetate; In methanol; ethanol; toluene;
DOI:10.1016/j.bmc.2013.02.021

Reference yield:

: 75291-50-8
cyclohexyl-(4-nitro-1-oxy-pyridin-2-yl)-amine

: 1428958-79-5
cyclohexyl-{4-[2-(3,4-dichloro-phenyl)-5-methoxy-benzoimidazol-1-yl]-pyridin-2-yl}-amine

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / methanol / 9 h / 20 °C

2: palladium diacetate; BINAP; potassium phosphate / toluene / 3 h / 130 °C / Inert atmosphere

3: hydrogen; palladium on activated charcoal / methanol / 0.5 h / 20 °C

4: dihydrogen peroxide; ammonium cerium (IV) nitrate / ethanol / 8 h / 50 °C

With potassium phosphate; ammonium cerium (IV) nitrate; BINAP; palladium on activated charcoal; hydrogen; dihydrogen peroxide; palladium diacetate; In methanol; ethanol; toluene;
DOI:10.1016/j.bmc.2013.02.021