ethyl 2-methyl-5-oxo-1-phenyl-4-(phenylamino)-2,5-dihydro-1H-pyrrole-2-carboxylate

Base Information

• Chemical Name: ethyl 2-methyl-5-oxo-1-phenyl-4-(phenylamino)-2,5-dihydro-1H-pyrrole-2-carboxylate
• CAS No.: 31407-15-5
• Molecular Formula: C₂₀H₂₀N₂O₃
• Molecular Weight: 336.39
• Mol file: 31407-15-5.mol

Synonyms:ethyl 2-methyl-5-oxo-1-phenyl-4-(phenylamino)-2,5-dihydro-1H-pyrrole-2-carboxylate

Chemical Property of ethyl 2-methyl-5-oxo-1-phenyl-4-(phenylamino)-2,5-dihydro-1H-pyrrole-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of ethyl 2-methyl-5-oxo-1-phenyl-4-(phenylamino)-2,5-dihydro-1H-pyrrole-2-carboxylate

There total 1 articles about ethyl 2-methyl-5-oxo-1-phenyl-4-(phenylamino)-2,5-dihydro-1H-pyrrole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-oxo-propionic acid ethyl ester (617-35-6) + aniline (62-53-3) → ethyl 2-methyl-5-oxo-1-phenyl-4-(phenylamino)-2,5-dihydro-1H-pyrrole-2-carboxylate (31407-15-5)

Guidance literature:

With CoFe₂O₄ nanoparticles base catalyst; In ethanol; water; for 0.166667h; Reagent/catalyst; Solvent; Catalytic behavior; Microwave irradiation; Green chemistry;

DOI:10.1002/aoc.3536

Reference yield: 63.0%

ethyl 2-methyl-5-oxo-1-phenyl-4-(phenylamino)-2,5-dihydro-1H-pyrrole-2-carboxylate (31407-15-5) → ethyl 2-methyl-4,5-dioxo-1-phenyl-2-pyrrolidinecarboxylate (223392-83-4)

Guidance literature:

With hydrogenchloride; at 18 - 20 ℃; for 24h;

Reference yield: 53.0%

oxalyl dichloride (79-37-8) + ethyl 2-methyl-5-oxo-1-phenyl-4-(phenylamino)-2,5-dihydro-1H-pyrrole-2-carboxylate (31407-15-5) → N,N'-di(5-methyl-5-ethoxycarbonyl-2-oxo-1-phenyl-2,5-dihydropyrrol-3-yl)-N,N'-diphenyloxalylamide (1364697-03-9) + ethyl 4-methyl-2,3,6-trioxo-1,5-diphenyl-1,2,3,4,5,6-hexahydropyrrolo<3,4-b>pyrrole-4-carboxylate

Guidance literature:

In tetrachloromethane; Reflux;

DOI:10.1134/S1070428012020224

upstream raw materials:

2-oxo-propionic acid ethyl ester

aniline

Downstream raw materials:

ethyl 2-methyl-4,5-dioxo-1-phenyl-2-pyrrolidinecarboxylate

N,N'-di(5-methyl-5-ethoxycarbonyl-2-oxo-1-phenyl-2,5-dihydropyrrol-3-yl)-N,N'-diphenyloxalylamide