Technology Process of N-{[8-(3-bromo-5-fluorophenyl)-6-hydroxy-5-quinoxalinyl]carbonyl}glycine
There total 8 articles about N-{[8-(3-bromo-5-fluorophenyl)-6-hydroxy-5-quinoxalinyl]carbonyl}glycine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(3-bromo-5-fluorophenyl)boronic acid; ethyl N-[(8-bromo-6-hydroxy-5-quinoxalinyl)carbonyl]glycinate;
With
potassium carbonate;
tetrakis(triphenylphosphine) palladium(0);
In
1,4-dioxane; water;
at 120 ℃;
for 1h;
Microwave irradiation;
With
water; sodium hydroxide;
In
1,4-dioxane; methanol;
at 20 ℃;
for 0.5h;
With
hydrogenchloride;
In
1,4-dioxane; methanol; water;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sulfuric acid; nitric acid / 0 - 20 °C
2.1: ammonium hydroxide / methanol; water / 20 °C
3.1: sodium methylate / methanol / 0 - 20 °C
4.1: hydrogen / palladium on activated charcoal / methanol / 2 h
4.2: 2 h / Reflux
5.1: boron tribromide / dichloromethane / 20 °C
6.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 2 h / 20 °C
7.1: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 1 h / 120 °C / Microwave irradiation
7.2: 0.5 h / 20 °C
With
ammonium hydroxide; sulfuric acid; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; nitric acid; sodium methylate; boron tribromide; potassium carbonate; triethylamine;
tetrakis(triphenylphosphine) palladium(0); palladium on activated charcoal;
In
1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 2 h / 20 °C
2.1: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 1 h / 120 °C / Microwave irradiation
2.2: 0.5 h / 20 °C
With
benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; potassium carbonate; triethylamine;
tetrakis(triphenylphosphine) palladium(0);
In
1,4-dioxane; water; N,N-dimethyl-formamide;
