1-{4-Chloro-3-[2-(2-dimethylamino-ethylamino)-8-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl]-phenyl}-3-(3-chloro-4-methoxy-phenyl)-urea

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Chemical Name:1-{4-Chloro-3-[2-(2-dimethylamino-ethylamino)-8-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl]-phenyl}-3-(3-chloro-4-methoxy-phenyl)-urea
CAS No.:1192309-52-6
Molecular Formula:C₂₆H₂₇Cl₂N₇O₄
Molecular Weight:572.451
Hs Code.:

Synonyms:1-{4-Chloro-3-[2-(2-dimethylamino-ethylamino)-8-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl]-phenyl}-3-(3-chloro-4-methoxy-phenyl)-urea

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Chemical Property of 1-{4-Chloro-3-[2-(2-dimethylamino-ethylamino)-8-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl]-phenyl}-3-(3-chloro-4-methoxy-phenyl)-urea

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Technology Process of 1-{4-Chloro-3-[2-(2-dimethylamino-ethylamino)-8-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl]-phenyl}-3-(3-chloro-4-methoxy-phenyl)-urea

There total 10 articles about 1-{4-Chloro-3-[2-(2-dimethylamino-ethylamino)-8-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl]-phenyl}-3-(3-chloro-4-methoxy-phenyl)-urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1192310-18-1
6-(5-amino-2-chlorophenyl)-2-(2-(dimethylamino)ethylamino)-8-methoxypyrido[2,3-d]pyrimidin-7(8H)-one

: 28395-76-8
3-chloro-4-methoxyphenylisocyanate

: 1192309-52-6
1-{4-Chloro-3-[2-(2-dimethylamino-ethylamino)-8-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl]-phenyl}-3-(3-chloro-4-methoxy-phenyl)-urea

Guidance literature:: In tetrahydrofuran; at 20 ℃;

Reference yield:

: 2444-36-2
2'-chloro-benzeneacetic acid

: 1192309-52-6
1-{4-Chloro-3-[2-(2-dimethylamino-ethylamino)-8-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl]-phenyl}-3-(3-chloro-4-methoxy-phenyl)-urea

Guidance literature:: Multi-step reaction with 7 steps

1: nitric acid; sulfuric acid / water / 5 h / -10 - 0 °C

2: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 4 h / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide

4: dihydrogen peroxide / sodium tungstate (VI) dihydrate / water; acetic acid / 18 h / 20 °C / Inert atmosphere

5: hydrogenchloride / isopropyl alcohol; water / 0.25 h / 100 °C / Microwave irradiation; Sealed vessel

6: hydrogenchloride; iron / ethanol / 6 h / 80 °C

7: tetrahydrofuran / 20 °C

With hydrogenchloride; sulfuric acid; dihydrogen peroxide; nitric acid; iron; potassium carbonate; 1,1'-carbonyldiimidazole; sodium tungstate (VI) dihydrate; In tetrahydrofuran; ethanol; water; acetic acid; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 37777-70-1
2-(2-chloro-5-nitrophenyl)acetic acid

: 1192309-52-6
1-{4-Chloro-3-[2-(2-dimethylamino-ethylamino)-8-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl]-phenyl}-3-(3-chloro-4-methoxy-phenyl)-urea

Guidance literature:: Multi-step reaction with 6 steps

1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 4 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide

3: dihydrogen peroxide / sodium tungstate (VI) dihydrate / water; acetic acid / 18 h / 20 °C / Inert atmosphere

4: hydrogenchloride / isopropyl alcohol; water / 0.25 h / 100 °C / Microwave irradiation; Sealed vessel

5: hydrogenchloride; iron / ethanol / 6 h / 80 °C

6: tetrahydrofuran / 20 °C

With hydrogenchloride; dihydrogen peroxide; iron; potassium carbonate; 1,1'-carbonyldiimidazole; sodium tungstate (VI) dihydrate; In tetrahydrofuran; ethanol; water; acetic acid; N,N-dimethyl-formamide; isopropyl alcohol;