6-N,N-Dibenzoyl-9-<2-deoxy-3-O-methanesulphonyl-5-O-(4-monomethoxytrityl)-β-D-threo-pentofuranosyl>adenine

Base Information

Chemical Name:6-N,N-Dibenzoyl-9-<2-deoxy-3-O-methanesulphonyl-5-O-(4-monomethoxytrityl)-β-D-threo-pentofuranosyl>adenine
CAS No.:141690-79-1
Molecular Formula:C₄₅H₃₉N₅O₈S
Molecular Weight:809.899
Hs Code.:

Synonyms:6-N,N-Dibenzoyl-9-<2-deoxy-3-O-methanesulphonyl-5-O-(4-monomethoxytrityl)-β-D-threo-pentofuranosyl>adenine

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Chemical Property of 6-N,N-Dibenzoyl-9-<2-deoxy-3-O-methanesulphonyl-5-O-(4-monomethoxytrityl)-β-D-threo-pentofuranosyl>adenine

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Technology Process of 6-N,N-Dibenzoyl-9-<2-deoxy-3-O-methanesulphonyl-5-O-(4-monomethoxytrityl)-β-D-threo-pentofuranosyl>adenine

There total 9 articles about 6-N,N-Dibenzoyl-9-<2-deoxy-3-O-methanesulphonyl-5-O-(4-monomethoxytrityl)-β-D-threo-pentofuranosyl>adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 98-88-4
benzoyl chloride

: 108895-41-6
9-<2-Deoxy-3-O-methanesulphonyl-5-O-(4-monomethoxytrityl)-β-D-threo-pentofuranosyl>adenine

: 141690-78-0
6-N-Benzoyl-9-<2-deoxy-3-O-methanesulphonyl-5-O-(4-monomethoxytrityl)-β-D-threo-pentofuranosyl>adenine

: 141690-79-1
6-N,N-Dibenzoyl-9-<2-deoxy-3-O-methanesulphonyl-5-O-(4-monomethoxytrityl)-β-D-threo-pentofuranosyl>adenine

Guidance literature:: With pyridine; at 0 ℃; for 4h;
DOI:10.1016/S0040-4020(01)88532-X

Reference yield:

: 29391-35-3
((2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1 (2H)-yl)tetrahydrofuran-2-yl)methyl methanesulfonate

: 141690-79-1
6-N,N-Dibenzoyl-9-<2-deoxy-3-O-methanesulphonyl-5-O-(4-monomethoxytrityl)-β-D-threo-pentofuranosyl>adenine

Guidance literature:: Multi-step reaction with 8 steps

1: LiN₃ / dimethylformamide / 4 h / 80 °C

2: H₂ / 10 percent Pd/C / ethanol / 4 h

3: pyridine

4: DMAP; pyridine / 12 h

5: DCC; pyridine / dioxane

6: pyridine / 10 h / 0 - 20 °C

7: 3 h / 0 - 20 °C

With pyridine; dmap; lithium azide; hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(03)00119-7

Reference yield:

: 19316-85-9
5'-azido-5'-deoxythymidine

: 141690-79-1
6-N,N-Dibenzoyl-9-<2-deoxy-3-O-methanesulphonyl-5-O-(4-monomethoxytrityl)-β-D-threo-pentofuranosyl>adenine

Guidance literature:: Multi-step reaction with 7 steps

1: H₂ / 10 percent Pd/C / ethanol / 4 h

2: pyridine

3: DMAP; pyridine / 12 h

4: DCC; pyridine / dioxane

5: pyridine / 10 h / 0 - 20 °C

6: 3 h / 0 - 20 °C

With pyridine; dmap; hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In 1,4-dioxane; ethanol;
DOI:10.1016/S0960-894X(03)00119-7