4-(4-methoxyhenyl)morpholine nitric acid salt

Base Information

• Chemical Name: 4-(4-methoxyhenyl)morpholine nitric acid salt
• CAS No.: 955095-74-6
• Molecular Formula: C₁₁H₁₅NO₂*HNO₃
• Molecular Weight: 256.258
• Mol file: 955095-74-6.mol

Synonyms:4-(4-methoxyhenyl)morpholine nitric acid salt

Chemical Property of 4-(4-methoxyhenyl)morpholine nitric acid salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 4-(4-methoxyhenyl)morpholine nitric acid salt

There total 3 articles about 4-(4-methoxyhenyl)morpholine nitric acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-methoxy-aniline (104-94-9) + 3-oxa-1,5-dichloropentane (111-44-4) → 4-(4-methoxyhenyl)morpholine nitric acid salt (955095-74-6)

Guidance literature:

4-methoxy-aniline; 3-oxa-1,5-dichloropentane; With tetrabutylammomium bromide; sodium hydroxide; for 8h; Heating;

With nitric acid; at 0 - 5 ℃; for 12h;

DOI:10.1016/j.ejmech.2021.113214

Reference yield:

N-(4-methoxyphenyl)morpholine (27347-14-4) → 4-(4-methoxyhenyl)morpholine nitric acid salt (955095-74-6)

Guidance literature:

With nitric acid; In tert-butyl methyl ether; water; ethyl acetate; at 0 ℃; for 1h;

Reference yield:

4-methoxy-aniline (104-94-9) → 4-(4-methoxyhenyl)morpholine nitric acid salt (955095-74-6)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrabutylammomium bromide; sodium hydroxide / 8 h / 110 °C

2: nitric acid / 0 °C

With tetrabutylammomium bromide; nitric acid; sodium hydroxide;

DOI:10.1021/op700074k

upstream raw materials:

N-(4-methoxyphenyl)morpholine

4-methoxy-aniline

3-oxa-1,5-dichloropentane

Downstream raw materials:

4-(4-methoxy-3-nitrophenyl)morpholine

4-(4-methoxy-2-nitro-phenyl)morpholine

Tozadenant

(2-methoxy-5-morpholin-4-yl-phenyl)thiourea

Refernces

• 1、 -. "Mono-nitration of aromatic compounds via nitrate salts". Page/Page column 7; 8-9. . Retrieved 2008/06/13.